A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst

[Image: see text] Macrolactonization of natural product analogs presents a significant challenge to both biosynthetic assembly and synthetic chemistry. In the preceding paper, we identified a thioesterase (TE) domain catalytic bottleneck processing unnatural substrates in the pikromycin (Pik) system...

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Detalles Bibliográficos
Autores principales: Koch, Aaron A., Hansen, Douglas A., Shende, Vikram V., Furan, Lawrence R., Houk, K. N., Jiménez-Osés, Gonzalo, Sherman, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617804/
https://www.ncbi.nlm.nih.gov/pubmed/28836768
http://dx.doi.org/10.1021/jacs.7b06436

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