Cargando…

The Role of Oocyte Organelles in Determining Developmental Competence

The ability of an oocyte to undergo successful cytoplasmic and nuclear maturation, fertilization and embryo development is referred to as the oocyte’s quality or developmental competence. Quality is dependent on the accumulation of organelles, metabolites and maternal RNAs during the growth and matu...

Descripción completa

Detalles Bibliográficos
Autores principales: Reader, Karen L., Stanton, Jo-Ann L., Juengel, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617923/
https://www.ncbi.nlm.nih.gov/pubmed/28927010
http://dx.doi.org/10.3390/biology6030035
_version_ 1783267070166695936
author Reader, Karen L.
Stanton, Jo-Ann L.
Juengel, Jennifer L.
author_facet Reader, Karen L.
Stanton, Jo-Ann L.
Juengel, Jennifer L.
author_sort Reader, Karen L.
collection PubMed
description The ability of an oocyte to undergo successful cytoplasmic and nuclear maturation, fertilization and embryo development is referred to as the oocyte’s quality or developmental competence. Quality is dependent on the accumulation of organelles, metabolites and maternal RNAs during the growth and maturation of the oocyte. Various models of good and poor oocyte quality have been used to understand the essential contributors to developmental success. This review covers the current knowledge of how oocyte organelle quantity, distribution and morphology differ between good and poor quality oocytes. The models of oocyte quality are also described and their usefulness for studying the intrinsic quality of an oocyte discussed. Understanding the key critical features of cytoplasmic organelles and metabolites driving oocyte quality will lead to methods for identifying high quality oocytes and improving oocyte competence, both in vitro and in vivo.
format Online
Article
Text
id pubmed-5617923
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-56179232017-09-29 The Role of Oocyte Organelles in Determining Developmental Competence Reader, Karen L. Stanton, Jo-Ann L. Juengel, Jennifer L. Biology (Basel) Review The ability of an oocyte to undergo successful cytoplasmic and nuclear maturation, fertilization and embryo development is referred to as the oocyte’s quality or developmental competence. Quality is dependent on the accumulation of organelles, metabolites and maternal RNAs during the growth and maturation of the oocyte. Various models of good and poor oocyte quality have been used to understand the essential contributors to developmental success. This review covers the current knowledge of how oocyte organelle quantity, distribution and morphology differ between good and poor quality oocytes. The models of oocyte quality are also described and their usefulness for studying the intrinsic quality of an oocyte discussed. Understanding the key critical features of cytoplasmic organelles and metabolites driving oocyte quality will lead to methods for identifying high quality oocytes and improving oocyte competence, both in vitro and in vivo. MDPI 2017-09-18 /pmc/articles/PMC5617923/ /pubmed/28927010 http://dx.doi.org/10.3390/biology6030035 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Reader, Karen L.
Stanton, Jo-Ann L.
Juengel, Jennifer L.
The Role of Oocyte Organelles in Determining Developmental Competence
title The Role of Oocyte Organelles in Determining Developmental Competence
title_full The Role of Oocyte Organelles in Determining Developmental Competence
title_fullStr The Role of Oocyte Organelles in Determining Developmental Competence
title_full_unstemmed The Role of Oocyte Organelles in Determining Developmental Competence
title_short The Role of Oocyte Organelles in Determining Developmental Competence
title_sort role of oocyte organelles in determining developmental competence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617923/
https://www.ncbi.nlm.nih.gov/pubmed/28927010
http://dx.doi.org/10.3390/biology6030035
work_keys_str_mv AT readerkarenl theroleofoocyteorganellesindeterminingdevelopmentalcompetence
AT stantonjoannl theroleofoocyteorganellesindeterminingdevelopmentalcompetence
AT juengeljenniferl theroleofoocyteorganellesindeterminingdevelopmentalcompetence
AT readerkarenl roleofoocyteorganellesindeterminingdevelopmentalcompetence
AT stantonjoannl roleofoocyteorganellesindeterminingdevelopmentalcompetence
AT juengeljenniferl roleofoocyteorganellesindeterminingdevelopmentalcompetence