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Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race
Geminiviruses are plant-infecting viruses characterized by a single-stranded DNA (ssDNA) genome. Geminivirus-derived proteins are multifunctional and effective regulators in modulating the host cellular processes resulting in successful infection. Virus-host interactions result in changes in host ge...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618022/ https://www.ncbi.nlm.nih.gov/pubmed/28914771 http://dx.doi.org/10.3390/v9090256 |
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author | Ramesh, Shunmugiah V. Sahu, Pranav P. Prasad, Manoj Praveen, Shelly Pappu, Hanu R. |
author_facet | Ramesh, Shunmugiah V. Sahu, Pranav P. Prasad, Manoj Praveen, Shelly Pappu, Hanu R. |
author_sort | Ramesh, Shunmugiah V. |
collection | PubMed |
description | Geminiviruses are plant-infecting viruses characterized by a single-stranded DNA (ssDNA) genome. Geminivirus-derived proteins are multifunctional and effective regulators in modulating the host cellular processes resulting in successful infection. Virus-host interactions result in changes in host gene expression patterns, reprogram plant signaling controls, disrupt central cellular metabolic pathways, impair plant’s defense system, and effectively evade RNA silencing response leading to host susceptibility. This review summarizes what is known about the cellular processes in the continuing tug of war between geminiviruses and their plant hosts at the molecular level. In addition, implications for engineered resistance to geminivirus infection in the context of a greater understanding of the molecular processes are also discussed. Finally, the prospect of employing geminivirus-based vectors in plant genome engineering and the emergence of powerful genome editing tools to confer geminivirus resistance are highlighted to complete the perspective on geminivirus-plant molecular interactions. |
format | Online Article Text |
id | pubmed-5618022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56180222017-09-29 Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race Ramesh, Shunmugiah V. Sahu, Pranav P. Prasad, Manoj Praveen, Shelly Pappu, Hanu R. Viruses Review Geminiviruses are plant-infecting viruses characterized by a single-stranded DNA (ssDNA) genome. Geminivirus-derived proteins are multifunctional and effective regulators in modulating the host cellular processes resulting in successful infection. Virus-host interactions result in changes in host gene expression patterns, reprogram plant signaling controls, disrupt central cellular metabolic pathways, impair plant’s defense system, and effectively evade RNA silencing response leading to host susceptibility. This review summarizes what is known about the cellular processes in the continuing tug of war between geminiviruses and their plant hosts at the molecular level. In addition, implications for engineered resistance to geminivirus infection in the context of a greater understanding of the molecular processes are also discussed. Finally, the prospect of employing geminivirus-based vectors in plant genome engineering and the emergence of powerful genome editing tools to confer geminivirus resistance are highlighted to complete the perspective on geminivirus-plant molecular interactions. MDPI 2017-09-15 /pmc/articles/PMC5618022/ /pubmed/28914771 http://dx.doi.org/10.3390/v9090256 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ramesh, Shunmugiah V. Sahu, Pranav P. Prasad, Manoj Praveen, Shelly Pappu, Hanu R. Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race |
title | Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race |
title_full | Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race |
title_fullStr | Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race |
title_full_unstemmed | Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race |
title_short | Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race |
title_sort | geminiviruses and plant hosts: a closer examination of the molecular arms race |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618022/ https://www.ncbi.nlm.nih.gov/pubmed/28914771 http://dx.doi.org/10.3390/v9090256 |
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