Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated prote...

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Detalles Bibliográficos
Autores principales: Thakur, Garima, Prashanthi, Kovur, Jiang, Keren, Thundat, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618250/
https://www.ncbi.nlm.nih.gov/pubmed/28930179
http://dx.doi.org/10.3390/biom7030069
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author Thakur, Garima
Prashanthi, Kovur
Jiang, Keren
Thundat, Thomas
author_facet Thakur, Garima
Prashanthi, Kovur
Jiang, Keren
Thundat, Thomas
author_sort Thakur, Garima
collection PubMed
description Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.
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spelling pubmed-56182502017-09-29 Self-Assembly of Human Serum Albumin: A Simplex Phenomenon Thakur, Garima Prashanthi, Kovur Jiang, Keren Thundat, Thomas Biomolecules Article Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics. MDPI 2017-09-20 /pmc/articles/PMC5618250/ /pubmed/28930179 http://dx.doi.org/10.3390/biom7030069 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thakur, Garima
Prashanthi, Kovur
Jiang, Keren
Thundat, Thomas
Self-Assembly of Human Serum Albumin: A Simplex Phenomenon
title Self-Assembly of Human Serum Albumin: A Simplex Phenomenon
title_full Self-Assembly of Human Serum Albumin: A Simplex Phenomenon
title_fullStr Self-Assembly of Human Serum Albumin: A Simplex Phenomenon
title_full_unstemmed Self-Assembly of Human Serum Albumin: A Simplex Phenomenon
title_short Self-Assembly of Human Serum Albumin: A Simplex Phenomenon
title_sort self-assembly of human serum albumin: a simplex phenomenon
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618250/
https://www.ncbi.nlm.nih.gov/pubmed/28930179
http://dx.doi.org/10.3390/biom7030069
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AT jiangkeren selfassemblyofhumanserumalbuminasimplexphenomenon
AT thundatthomas selfassemblyofhumanserumalbuminasimplexphenomenon

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