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Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis

Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present stu...

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Autores principales: Vaca-Cornejo, Fabiola, Reyes, Héctor Macías, Jiménez, Sergio H. Dueñas, Velázquez, Ricardo A. Llamas, Jiménez, Judith M. Dueñas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618280/
https://www.ncbi.nlm.nih.gov/pubmed/28753925
http://dx.doi.org/10.3390/jfb8030029
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author Vaca-Cornejo, Fabiola
Reyes, Héctor Macías
Jiménez, Sergio H. Dueñas
Velázquez, Ricardo A. Llamas
Jiménez, Judith M. Dueñas
author_facet Vaca-Cornejo, Fabiola
Reyes, Héctor Macías
Jiménez, Sergio H. Dueñas
Velázquez, Ricardo A. Llamas
Jiménez, Judith M. Dueñas
author_sort Vaca-Cornejo, Fabiola
collection PubMed
description Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis. Patients were evaluated through X-ray images and a millimetric slide over a one year period. The application of CH/HAP produced an average alveolar bone growth of 5.77 mm (±1.87 mm). At the onset of the study, the dental pocket exhibited a depth level (DPDL) of 8.66 mm and decreased to 3.55 mm one year after the implant. Tooth mobility grade was 2.44 mm at the onset and 0.8 mm at the end of the study with a significant difference of p < 0.001. Moreover, the bone density in the affected areas was similar to the density of the bone adjacent to it. This result was confirmed with the software implant viewer from Anne Solutions Company. In conclusion, the CH/HAP implant promoted alveolar bone growth in periodontitis patients.
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spelling pubmed-56182802017-09-29 Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis Vaca-Cornejo, Fabiola Reyes, Héctor Macías Jiménez, Sergio H. Dueñas Velázquez, Ricardo A. Llamas Jiménez, Judith M. Dueñas J Funct Biomater Article Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis. Patients were evaluated through X-ray images and a millimetric slide over a one year period. The application of CH/HAP produced an average alveolar bone growth of 5.77 mm (±1.87 mm). At the onset of the study, the dental pocket exhibited a depth level (DPDL) of 8.66 mm and decreased to 3.55 mm one year after the implant. Tooth mobility grade was 2.44 mm at the onset and 0.8 mm at the end of the study with a significant difference of p < 0.001. Moreover, the bone density in the affected areas was similar to the density of the bone adjacent to it. This result was confirmed with the software implant viewer from Anne Solutions Company. In conclusion, the CH/HAP implant promoted alveolar bone growth in periodontitis patients. MDPI 2017-07-19 /pmc/articles/PMC5618280/ /pubmed/28753925 http://dx.doi.org/10.3390/jfb8030029 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vaca-Cornejo, Fabiola
Reyes, Héctor Macías
Jiménez, Sergio H. Dueñas
Velázquez, Ricardo A. Llamas
Jiménez, Judith M. Dueñas
Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
title Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
title_full Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
title_fullStr Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
title_full_unstemmed Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
title_short Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis
title_sort pilot study using a chitosan-hydroxyapatite implant for guided alveolar bone growth in patients with chronic periodontitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618280/
https://www.ncbi.nlm.nih.gov/pubmed/28753925
http://dx.doi.org/10.3390/jfb8030029
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