Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?

After more than a decade of preclinical and clinical development, therapeutic infusion of mesenchymal stromal cells is now a leading investigational strategy for the treatment of acute graft-versus-host disease (GVHD). While their clinical use continues to expand, it is still unknown which of their...

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Detalles Bibliográficos
Autores principales: Dunavin, Neil, Dias, Ajoy, Li, Meizhang, McGuirk, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618297/
https://www.ncbi.nlm.nih.gov/pubmed/28671556
http://dx.doi.org/10.3390/biomedicines5030039
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author Dunavin, Neil
Dias, Ajoy
Li, Meizhang
McGuirk, Joseph
author_facet Dunavin, Neil
Dias, Ajoy
Li, Meizhang
McGuirk, Joseph
author_sort Dunavin, Neil
collection PubMed
description After more than a decade of preclinical and clinical development, therapeutic infusion of mesenchymal stromal cells is now a leading investigational strategy for the treatment of acute graft-versus-host disease (GVHD). While their clinical use continues to expand, it is still unknown which of their immunomodulatory properties contributes most to their therapeutic activity. Herein we describe the proposed mechanisms, focusing on the inhibitory activity of mesenchymal stromal cells (MSCs) at immunologic checkpoints. A deeper understanding of the mechanism of action will allow us to design more effective treatment strategies.
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spelling pubmed-56182972017-09-29 Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease? Dunavin, Neil Dias, Ajoy Li, Meizhang McGuirk, Joseph Biomedicines Review After more than a decade of preclinical and clinical development, therapeutic infusion of mesenchymal stromal cells is now a leading investigational strategy for the treatment of acute graft-versus-host disease (GVHD). While their clinical use continues to expand, it is still unknown which of their immunomodulatory properties contributes most to their therapeutic activity. Herein we describe the proposed mechanisms, focusing on the inhibitory activity of mesenchymal stromal cells (MSCs) at immunologic checkpoints. A deeper understanding of the mechanism of action will allow us to design more effective treatment strategies. MDPI 2017-07-01 /pmc/articles/PMC5618297/ /pubmed/28671556 http://dx.doi.org/10.3390/biomedicines5030039 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dunavin, Neil
Dias, Ajoy
Li, Meizhang
McGuirk, Joseph
Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
title Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
title_full Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
title_fullStr Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
title_full_unstemmed Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
title_short Mesenchymal Stromal Cells: What Is the Mechanism in Acute Graft-Versus-Host Disease?
title_sort mesenchymal stromal cells: what is the mechanism in acute graft-versus-host disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618297/
https://www.ncbi.nlm.nih.gov/pubmed/28671556
http://dx.doi.org/10.3390/biomedicines5030039
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AT limeizhang mesenchymalstromalcellswhatisthemechanisminacutegraftversushostdisease
AT mcguirkjoseph mesenchymalstromalcellswhatisthemechanisminacutegraftversushostdisease

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