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In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus

The increasing occurrence of antibiotic-resistant Staphylococcus (S.) aureus tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed. The use of naturally derived materials might become a more promising concept,...

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Autores principales: Yaseen, Ragheda, Branitzki-Heinemann, Katja, Moubasher, Hani, Setzer, William N., Naim, Hassan Y., von Köckritz-Blickwede, Maren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618298/
https://www.ncbi.nlm.nih.gov/pubmed/28678207
http://dx.doi.org/10.3390/biomedicines5030040
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author Yaseen, Ragheda
Branitzki-Heinemann, Katja
Moubasher, Hani
Setzer, William N.
Naim, Hassan Y.
von Köckritz-Blickwede, Maren
author_facet Yaseen, Ragheda
Branitzki-Heinemann, Katja
Moubasher, Hani
Setzer, William N.
Naim, Hassan Y.
von Köckritz-Blickwede, Maren
author_sort Yaseen, Ragheda
collection PubMed
description The increasing occurrence of antibiotic-resistant Staphylococcus (S.) aureus tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed. The use of naturally derived materials might become a more promising concept, not only as directly acting antimicrobials, but also for stimulation of the immune system. Costa Rican plant extracts were screened for their ability to enhance the antimicrobial activity of human blood-derived cells against S. aureus infections. We identified three plant extracts which significantly reduced the growth of S. aureus in the presence of human blood without directly acting as antibacterials: Byrsonima crassifolia acetone bark extract, Mandevilla veraguasensis acetone vine extract and Verbesina oerstediana acetone bark extract (VEOEBA). The effect of VEOEBA was studied in more detail, and revealed that VEOEBA increases the antimicrobial activity of neutrophils by enhancing the formation of neutrophil extracellular traps.
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spelling pubmed-56182982017-09-29 In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus Yaseen, Ragheda Branitzki-Heinemann, Katja Moubasher, Hani Setzer, William N. Naim, Hassan Y. von Köckritz-Blickwede, Maren Biomedicines Article The increasing occurrence of antibiotic-resistant Staphylococcus (S.) aureus tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed. The use of naturally derived materials might become a more promising concept, not only as directly acting antimicrobials, but also for stimulation of the immune system. Costa Rican plant extracts were screened for their ability to enhance the antimicrobial activity of human blood-derived cells against S. aureus infections. We identified three plant extracts which significantly reduced the growth of S. aureus in the presence of human blood without directly acting as antibacterials: Byrsonima crassifolia acetone bark extract, Mandevilla veraguasensis acetone vine extract and Verbesina oerstediana acetone bark extract (VEOEBA). The effect of VEOEBA was studied in more detail, and revealed that VEOEBA increases the antimicrobial activity of neutrophils by enhancing the formation of neutrophil extracellular traps. MDPI 2017-07-05 /pmc/articles/PMC5618298/ /pubmed/28678207 http://dx.doi.org/10.3390/biomedicines5030040 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yaseen, Ragheda
Branitzki-Heinemann, Katja
Moubasher, Hani
Setzer, William N.
Naim, Hassan Y.
von Köckritz-Blickwede, Maren
In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
title In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
title_full In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
title_fullStr In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
title_full_unstemmed In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
title_short In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus
title_sort in vitro testing of crude natural plant extracts from costa rica for their ability to boost innate immune cells against staphylococcus aureus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618298/
https://www.ncbi.nlm.nih.gov/pubmed/28678207
http://dx.doi.org/10.3390/biomedicines5030040
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