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Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus
Overwhelming evidence indicates that aspirin and related non-steroidal anti-inflammatory drugs (NSAIDs) have anti-tumour activity and the potential to prevent cancer, particularly colorectal cancer. However, the mechanisms underlying this effect remain hypothetical. Dysregulation of the nuclear fact...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618301/ https://www.ncbi.nlm.nih.gov/pubmed/28718829 http://dx.doi.org/10.3390/biomedicines5030043 |
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author | Chen, Jingyu Stark, Lesley A. |
author_facet | Chen, Jingyu Stark, Lesley A. |
author_sort | Chen, Jingyu |
collection | PubMed |
description | Overwhelming evidence indicates that aspirin and related non-steroidal anti-inflammatory drugs (NSAIDs) have anti-tumour activity and the potential to prevent cancer, particularly colorectal cancer. However, the mechanisms underlying this effect remain hypothetical. Dysregulation of the nuclear factor-kappaB (NF-κB) transcription factor is a common event in many cancer types which contributes to tumour initiation and progression by driving expression of pro-proliferative/anti-apoptotic genes. In this review, we will focus on the current knowledge regarding NSAID effects on the NF-κB signalling pathway in pre-cancerous and cancerous lesions, and the evidence that these effects contribute to the anti-tumour activity of the agents. The nuclear organelle, the nucleolus, is emerging as a central regulator of transcription factor activity and cell growth and death. Nucleolar function is dysregulated in the majority of cancers which promotes cancer growth through direct and indirect mechanisms. Hence, this organelle is emerging as a promising target for novel therapeutic agents. Here, we will also discuss evidence for crosstalk between the NF-κB pathway and nucleoli, the role that this cross-talk has in the anti-tumour effects of NSAIDs and ways forward to exploit this crosstalk for therapeutic purpose. |
format | Online Article Text |
id | pubmed-5618301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56183012017-09-29 Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus Chen, Jingyu Stark, Lesley A. Biomedicines Review Overwhelming evidence indicates that aspirin and related non-steroidal anti-inflammatory drugs (NSAIDs) have anti-tumour activity and the potential to prevent cancer, particularly colorectal cancer. However, the mechanisms underlying this effect remain hypothetical. Dysregulation of the nuclear factor-kappaB (NF-κB) transcription factor is a common event in many cancer types which contributes to tumour initiation and progression by driving expression of pro-proliferative/anti-apoptotic genes. In this review, we will focus on the current knowledge regarding NSAID effects on the NF-κB signalling pathway in pre-cancerous and cancerous lesions, and the evidence that these effects contribute to the anti-tumour activity of the agents. The nuclear organelle, the nucleolus, is emerging as a central regulator of transcription factor activity and cell growth and death. Nucleolar function is dysregulated in the majority of cancers which promotes cancer growth through direct and indirect mechanisms. Hence, this organelle is emerging as a promising target for novel therapeutic agents. Here, we will also discuss evidence for crosstalk between the NF-κB pathway and nucleoli, the role that this cross-talk has in the anti-tumour effects of NSAIDs and ways forward to exploit this crosstalk for therapeutic purpose. MDPI 2017-07-18 /pmc/articles/PMC5618301/ /pubmed/28718829 http://dx.doi.org/10.3390/biomedicines5030043 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Jingyu Stark, Lesley A. Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus |
title | Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus |
title_full | Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus |
title_fullStr | Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus |
title_full_unstemmed | Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus |
title_short | Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus |
title_sort | aspirin prevention of colorectal cancer: focus on nf-κb signalling and the nucleolus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618301/ https://www.ncbi.nlm.nih.gov/pubmed/28718829 http://dx.doi.org/10.3390/biomedicines5030043 |
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