Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo

Background: Like Duchenne muscular dystrophy (DMD), the Golden Retriever Muscular Dystrophy (GRMD) dog model of DMD is characterized by muscle necrosis, progressive paralysis, and pseudohypertrophy in specific skeletal muscles. This severe GRMD phenotype includes moderate atrophy of the biceps femor...

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Detalles Bibliográficos
Autores principales: Abdullah, Muhammad, Kornegay, Joe N., Honcoop, Aubree, Parry, Traci L., Balog-Alvarez, Cynthia J., O’Neal, Sara K., Bain, James R., Muehlbauer, Michael J., Newgard, Christopher B., Patterson, Cam, Willis, Monte S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618323/
https://www.ncbi.nlm.nih.gov/pubmed/28758940
http://dx.doi.org/10.3390/metabo7030038

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