Cargando…

Hydrocarbon constrained peptides – understanding preorganisation and binding affinity

The development of constrained peptides represents an emerging strategy to generate peptide based probes and hits for drug-discovery that address challenging protein–protein interactions (PPIs). In this manuscript we report on the use of a novel α-alkenylglycine derived amino acid to synthesise hydr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miles, Jennifer A., Yeo, David J., Rowell, Philip, Rodriguez-Marin, Silvia, Pask, Christopher M., Warriner, Stuart L., Edwards, Thomas A., Wilson, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618334/ https://www.ncbi.nlm.nih.gov/pubmed/28970875 http://dx.doi.org/10.1039/c5sc04048e

Ejemplares similares

Recognition of ASF1 by Using Hydrocarbon‐Constrained Peptides
por: Bakail, May, et al.
Publicado: (2019)

Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation
por: Fisher, Gemma, et al.
Publicado: (2022)

A Fluorescent Protein Scaffold for Presenting Structurally Constrained Peptides Provides an Effective Screening System to Identify High Affinity Target-Binding Peptides
por: Kadonosono, Tetsuya, et al.
Publicado: (2014)

Double quick, double click reversible peptide “stapling”
por: Grison, Claire M., et al.
Publicado: (2017)

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
por: Phillips, Angela M, et al.
Publicado: (2021)

Selection for constrained peptides that bind to a single target protein
por: King, Andrew M., et al.
Publicado: (2021)

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1
por: Rao, Tara, et al.
Publicado: (2013)

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers
por: Azzarito, Valeria, et al.
Publicado: (2015)

Oligomerization of Peptides LVEALYL and RGFFYT and Their Binding Affinity to Insulin
por: Chiang, Hsin-Lin, et al.
Publicado: (2013)

Fc-Binding Ligands of Immunoglobulin G: An Overview of High Affinity Proteins and Peptides
por: Choe, Weonu, et al.
Publicado: (2016)

Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
por: Srdanović, Sonja, et al.
Publicado: (2022)

Affinity-enhanced RNA-binding domains as tools to understand RNA recognition
por: Chaves-Arquero, Belén, et al.
Publicado: (2023)

Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces
por: Lama, Dilraj, et al.
Publicado: (2013)

Enhancement of Binding Affinity of Folate to Its Receptor by Peptide Conjugation
por: Dharmatti, Roopa, et al.
Publicado: (2019)

Predicting MHC-peptide binding affinity by differential boundary tree
por: Feng, Peiyuan, et al.
Publicado: (2021)

Determination of the affinity constants for phage display albumin-binding peptides
por: Shi, Yi-Feng
Publicado: (2023)

High-Affinity Anion Binding by Steroidal Squaramide Receptors**
por: Edwards, Sophie J, et al.
Publicado: (2015)

Peptides in headlock – a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy
por: Braun, Michael B., et al.
Publicado: (2016)

PPI-Affinity: A Web Tool for the Prediction and Optimization of Protein–Peptide and Protein–Protein Binding Affinity
por: Romero-Molina, Sandra, et al.
Publicado: (2022)

Low-Affinity Major Histocompatibility Complex–Binding Peptides in Type 1 Diabetes
por: James, Eddie A., et al.
Publicado: (2008)

Hydrocarbons and halogenated hydrocarbons in the aquatic environment
por: Afghan, B, et al.
Publicado: (1980)

A catalytic protein–proteomimetic complex: using aromatic oligoamide foldamers as activators of RNase S
por: Hegedus, Zsofia, et al.
Publicado: (2019)

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics
por: Burslem, George M., et al.
Publicado: (2016)

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity
por: Davies, Matthew N, et al.
Publicado: (2006)

General Approach for Characterizing In Vitro Selected Peptides with Protein Binding Affinity
por: Larsen, Andrew C., et al.
Publicado: (2014)

Hydrocarbon Stapled Antimicrobial Peptides
por: Migoń, Dorian, et al.
Publicado: (2018)

An In Silico Analysis of the Binding Modes and Binding Affinities of Small Molecule Modulators of PDZ-Peptide Interactions
por: Tiwari, Garima, et al.
Publicado: (2013)

Constrained Peptides as Miniature Protein Structures
por: Yin, Hang
Publicado: (2012)

Understanding Lignin-Degrading Reactions of Ligninolytic Enzymes: Binding Affinity and Interactional Profile
por: Chen, Ming, et al.
Publicado: (2011)

Chemical generation and modification of peptides containing multiple dehydroalanines
por: Morrison, Philip M., et al.
Publicado: (2015)

Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study
por: Srdanović, Sonja, et al.
Publicado: (2022)

The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins
por: Salomonsson, Emma, et al.
Publicado: (2011)

Peptides with the Same Composition, Hydrophobicity, and Hydrophobic Moment Bind to Phospholipid Bilayers with Different Affinities
por: Cherry, Melissa A., et al.
Publicado: (2014)

Accurate de novo design of hyperstable constrained peptides
por: Bhardwaj, Gaurav, et al.
Publicado: (2016)

Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA
por: Joce, Catherine, et al.
Publicado: (2009)

Rational design of Harakiri (HRK)-derived constrained peptides as BCL-x(L) inhibitors
por: Zhang, Peiyu, et al.
Publicado: (2023)

Understanding VPAC receptor family peptide binding and selectivity
por: Piper, Sarah J., et al.
Publicado: (2022)

Learning a peptide-protein binding affinity predictor with kernel ridge regression
por: Giguère, Sébastien, et al.
Publicado: (2013)

Affinity and Specificity for Binding to Glycosaminoglycans Can Be Tuned by Adapting Peptide Length and Sequence
por: Crijns, Helena, et al.
Publicado: (2021)

Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model
por: Bordner, Andrew J, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_gcc3d94mj6el37a44f4a93ehap