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Hydrocarbon constrained peptides – understanding preorganisation and binding affinity

The development of constrained peptides represents an emerging strategy to generate peptide based probes and hits for drug-discovery that address challenging protein–protein interactions (PPIs). In this manuscript we report on the use of a novel α-alkenylglycine derived amino acid to synthesise hydr...

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Detalles Bibliográficos
Autores principales:	Miles, Jennifer A., Yeo, David J., Rowell, Philip, Rodriguez-Marin, Silvia, Pask, Christopher M., Warriner, Stuart L., Edwards, Thomas A., Wilson, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618334/ https://www.ncbi.nlm.nih.gov/pubmed/28970875 http://dx.doi.org/10.1039/c5sc04048e

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