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Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structure...

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Autores principales: Huang, Chiung-Yao, Su, Jui-Hsin, Liaw, Chih-Chuang, Sung, Ping-Jyun, Chiang, Pei-Lun, Hwang, Tsong-Long, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618419/
https://www.ncbi.nlm.nih.gov/pubmed/28862648
http://dx.doi.org/10.3390/md15090280
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author Huang, Chiung-Yao
Su, Jui-Hsin
Liaw, Chih-Chuang
Sung, Ping-Jyun
Chiang, Pei-Lun
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Huang, Chiung-Yao
Su, Jui-Hsin
Liaw, Chih-Chuang
Sung, Ping-Jyun
Chiang, Pei-Lun
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Huang, Chiung-Yao
collection PubMed
description A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities.
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spelling pubmed-56184192017-09-30 Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank Huang, Chiung-Yao Su, Jui-Hsin Liaw, Chih-Chuang Sung, Ping-Jyun Chiang, Pei-Lun Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities. MDPI 2017-09-01 /pmc/articles/PMC5618419/ /pubmed/28862648 http://dx.doi.org/10.3390/md15090280 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Chiung-Yao
Su, Jui-Hsin
Liaw, Chih-Chuang
Sung, Ping-Jyun
Chiang, Pei-Lun
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
title Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
title_full Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
title_fullStr Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
title_full_unstemmed Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
title_short Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
title_sort bioactive steroids with methyl ester group in the side chain from a reef soft coral sinularia brassica cultured in a tank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618419/
https://www.ncbi.nlm.nih.gov/pubmed/28862648
http://dx.doi.org/10.3390/md15090280
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