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Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structure...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618419/ https://www.ncbi.nlm.nih.gov/pubmed/28862648 http://dx.doi.org/10.3390/md15090280 |
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author | Huang, Chiung-Yao Su, Jui-Hsin Liaw, Chih-Chuang Sung, Ping-Jyun Chiang, Pei-Lun Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng |
author_facet | Huang, Chiung-Yao Su, Jui-Hsin Liaw, Chih-Chuang Sung, Ping-Jyun Chiang, Pei-Lun Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng |
author_sort | Huang, Chiung-Yao |
collection | PubMed |
description | A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities. |
format | Online Article Text |
id | pubmed-5618419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56184192017-09-30 Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank Huang, Chiung-Yao Su, Jui-Hsin Liaw, Chih-Chuang Sung, Ping-Jyun Chiang, Pei-Lun Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities. MDPI 2017-09-01 /pmc/articles/PMC5618419/ /pubmed/28862648 http://dx.doi.org/10.3390/md15090280 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Chiung-Yao Su, Jui-Hsin Liaw, Chih-Chuang Sung, Ping-Jyun Chiang, Pei-Lun Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank |
title | Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank |
title_full | Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank |
title_fullStr | Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank |
title_full_unstemmed | Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank |
title_short | Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank |
title_sort | bioactive steroids with methyl ester group in the side chain from a reef soft coral sinularia brassica cultured in a tank |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618419/ https://www.ncbi.nlm.nih.gov/pubmed/28862648 http://dx.doi.org/10.3390/md15090280 |
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