Cargando…

APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel K(V)10.1

The human ether-à-go-go channel (hEag1 or K(V)10.1) is a cancer-relevant voltage-gated potassium channel that is overexpressed in a majority of human tumors. Peptides that are able to selectively inhibit this channel can be lead compounds in the search for new anticancer drugs. Here, we report the a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreels, Lien, Peigneur, Steve, Galan, Diogo T., De Pauw, Edwin, Béress, Lászlo, Waelkens, Etienne, Pardo, Luis A., Quinton, Loïc, Tytgat, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618426/ https://www.ncbi.nlm.nih.gov/pubmed/28902151 http://dx.doi.org/10.3390/md15090287

Ejemplares similares

Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone Heteractis magnifica
por: Kalina, Rimma S., et al.
Publicado: (2022)

Phyla- and Subtype-Selectivity of CgNa, a Na(+) Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis Gigantea
por: Billen, Bert, et al.
Publicado: (2010)

Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel K(V)10.1
por: Moreels, Lien, et al.
Publicado: (2017)

Interactions of Sea Anemone Toxins with Insect Sodium Channel—Insights from Electrophysiology and Molecular Docking Studies
por: Niklas, Beata, et al.
Publicado: (2021)

Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3
por: Jensen, Jonas E., et al.
Publicado: (2012)

Biochemical and Electrophysiological Characterization of Two Sea Anemone Type 1 Potassium Toxins from a Geographically Distant Population of Bunodosoma caissarum
por: Orts, Diego J. B., et al.
Publicado: (2013)

APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels
por: Kalina, Rimma S., et al.
Publicado: (2020)

AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels
por: An, Dongchen, et al.
Publicado: (2022)

New Insights into the Type II Toxins from the Sea Anemone Heteractis crispa
por: Kalina, Rimma S., et al.
Publicado: (2020)

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
por: Matsumura, Kazuki, et al.
Publicado: (2021)

Functional Expression in Escherichia coli of the Disulfide-Rich Sea Anemone Peptide APETx2, a Potent Blocker of Acid-Sensing Ion Channel 3
por: Anangi, Raveendra, et al.
Publicado: (2012)

A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels
por: Pinheiro-Junior, Ernesto Lopes, et al.
Publicado: (2022)

Kunitz-Type Peptides from the Sea Anemone Heteractis crispa Demonstrate Potassium Channel Blocking and Anti-Inflammatory Activities
por: Gladkikh, Irina, et al.
Publicado: (2020)

Screening and cDNA Cloning of Kv1 Potassium Channel Toxins in Sea Anemones
por: Yamaguchi, Yoshikazu, et al.
Publicado: (2010)

AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K(+) Channels Activation
por: B. Orts, Diego J., et al.
Publicado: (2018)

PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer
por: Rodríguez, Armando Alexei, et al.
Publicado: (2018)

Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds
por: Andreev, Yaroslav A., et al.
Publicado: (2018)

Toxins in Drug Discovery and Pharmacology
por: Peigneur, Steve, et al.
Publicado: (2018)

Sea Anemone Toxins: A Structural Overview
por: Madio, Bruno, et al.
Publicado: (2019)

Atypical Reactive Center Kunitz-Type Inhibitor from the Sea Anemone Heteractis crispa
por: Gladkikh, Irina, et al.
Publicado: (2012)

Preventing the induction of acid saline-induced fibromyalgia pain in mice by electroacupuncture or APETx2 injection
por: Yen, Liang-Ta, et al.
Publicado: (2020)

Sea Anemone (Cnidaria, Anthozoa, Actiniaria) Toxins: An Overview
por: Frazão, Bárbara, et al.
Publicado: (2012)

Peptide Toxins in Sea Anemones: Structural and Functional Aspects
por: Honma, Tomohiro, et al.
Publicado: (2006)

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins
por: J. Prentis, Peter, et al.
Publicado: (2018)

Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels
por: ElFessi-Magouri, Rym, et al.
Publicado: (2015)

Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins
por: Amorim, Fernanda Gobbi, et al.
Publicado: (2019)

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi
por: Peigneur, Steve, et al.
Publicado: (2019)

Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor
por: Monastyrnaya, Margarita, et al.
Publicado: (2016)

Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels
por: Kuzmenkov, Alexey I., et al.
Publicado: (2016)

De Novo Transcriptome Analysis of the Venom of Latrodectus geometricus with the Discovery of an Insect-Selective Na Channel Modulator
por: Khamtorn, Pornsawan, et al.
Publicado: (2021)

WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels
por: An, Dongchen, et al.
Publicado: (2021)

New Diarylamine K(V)10.1 Inhibitors and Their Anticancer Potential
por: Gubič, Špela, et al.
Publicado: (2022)

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins
por: Cremonez, Caroline M., et al.
Publicado: (2016)

Identification, Synthesis, Conformation and Activity of an Insulin-like Peptide from a Sea Anemone
por: Mitchell, Michela L., et al.
Publicado: (2021)

Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model
por: Sintsova, Oksana, et al.
Publicado: (2021)

Effect of sea anemone toxins on the sodium inactivation process in crayfish axons
Publicado: (1983)

Tentacle Morphological Variation Coincides with Differential Expression of Toxins in Sea Anemones
por: Ashwood, Lauren M., et al.
Publicado: (2021)

Magnificamide, a β-Defensin-Like Peptide from the Mucus of the Sea Anemone Heteractis magnifica, Is a Strong Inhibitor of Mammalian α-Amylases
por: Sintsova, Oksana, et al.
Publicado: (2019)

Multigene Family of Pore-Forming Toxins from Sea Anemone Heteractis crispa
por: Leychenko, Elena, et al.
Publicado: (2018)

3D Pharmacophore-Based Discovery of Novel K(V)10.1 Inhibitors with Antiproliferative Activity
por: Toplak, Žan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_002p3cqka4lrkqr30ilf0t9i2a