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Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children

BACKGROUND: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. METHODS: We conducted a cross-sectional pilot study of 10–13 year old healthy c...

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Autores principales: Kataria, Anglina, Levine, Dov, Wertenteil, Sara, Vento, Suzanne, Xue, Jingchuan, Rajendiran, Karthikraj, Kannan, Kurunthachalam, Thurman, Joshua M., Morrison, Debra, Brody, Rachel, Urbina, Elaine, Attina, Teresa, Trasande, Leonardo, Trachtman, Howard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618435/
https://www.ncbi.nlm.nih.gov/pubmed/28099427
http://dx.doi.org/10.1038/pr.2017.16
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author Kataria, Anglina
Levine, Dov
Wertenteil, Sara
Vento, Suzanne
Xue, Jingchuan
Rajendiran, Karthikraj
Kannan, Kurunthachalam
Thurman, Joshua M.
Morrison, Debra
Brody, Rachel
Urbina, Elaine
Attina, Teresa
Trasande, Leonardo
Trachtman, Howard
author_facet Kataria, Anglina
Levine, Dov
Wertenteil, Sara
Vento, Suzanne
Xue, Jingchuan
Rajendiran, Karthikraj
Kannan, Kurunthachalam
Thurman, Joshua M.
Morrison, Debra
Brody, Rachel
Urbina, Elaine
Attina, Teresa
Trasande, Leonardo
Trachtman, Howard
author_sort Kataria, Anglina
collection PubMed
description BACKGROUND: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. METHODS: We conducted a cross-sectional pilot study of 10–13 year old healthy children. We assessed descriptive, univariable and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction. Possible associations with brachial artery distensibility, pulse wave velocity (markers of vascular stiffness), and serum endothelial cell-derived microparticle levels were also assessed. RESULTS: We enrolled 41 participants, 12.1 ± 1.0 years, most of whom were Mexican-Americans (42%) or other Hispanics (34%). Increased BPA levels were associated with increased levels of F2-isoprostane (ng/ml) (P=0.02), with a similar trend for DEHP metabolites. Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with 0.550 increase in HOMA-IR units (p=0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P=0.026). Bisphenol S (BPS), a replacement for BPA, was associated with increased albumin (mg):creatinine (g) ratio (P=0.04). Metabolites of HMW phthalates were also associated with decreased brachial artery distensibility (P=0.047). CONCLUSIONS: Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children.
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spelling pubmed-56184352017-09-28 Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children Kataria, Anglina Levine, Dov Wertenteil, Sara Vento, Suzanne Xue, Jingchuan Rajendiran, Karthikraj Kannan, Kurunthachalam Thurman, Joshua M. Morrison, Debra Brody, Rachel Urbina, Elaine Attina, Teresa Trasande, Leonardo Trachtman, Howard Pediatr Res Article BACKGROUND: The health effects of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) have been studied extensively in children. The impact of other chemicals in these two classes has not been investigated as fully. METHODS: We conducted a cross-sectional pilot study of 10–13 year old healthy children. We assessed descriptive, univariable and multivariable associations of urinary metabolites of bisphenols and phthalates with oxidant stress, insulin resistance, body mass, and endothelial dysfunction. Possible associations with brachial artery distensibility, pulse wave velocity (markers of vascular stiffness), and serum endothelial cell-derived microparticle levels were also assessed. RESULTS: We enrolled 41 participants, 12.1 ± 1.0 years, most of whom were Mexican-Americans (42%) or other Hispanics (34%). Increased BPA levels were associated with increased levels of F2-isoprostane (ng/ml) (P=0.02), with a similar trend for DEHP metabolites. Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with 0.550 increase in HOMA-IR units (p=0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P=0.026). Bisphenol S (BPS), a replacement for BPA, was associated with increased albumin (mg):creatinine (g) ratio (P=0.04). Metabolites of HMW phthalates were also associated with decreased brachial artery distensibility (P=0.047). CONCLUSIONS: Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children. 2017-01-18 2017-06 /pmc/articles/PMC5618435/ /pubmed/28099427 http://dx.doi.org/10.1038/pr.2017.16 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kataria, Anglina
Levine, Dov
Wertenteil, Sara
Vento, Suzanne
Xue, Jingchuan
Rajendiran, Karthikraj
Kannan, Kurunthachalam
Thurman, Joshua M.
Morrison, Debra
Brody, Rachel
Urbina, Elaine
Attina, Teresa
Trasande, Leonardo
Trachtman, Howard
Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
title Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
title_full Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
title_fullStr Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
title_full_unstemmed Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
title_short Exposure to Bisphenols and Phthalates and Association with Oxidant Stress, InsulinN Resistance, and Endothelial Dysfunction in Children
title_sort exposure to bisphenols and phthalates and association with oxidant stress, insulinn resistance, and endothelial dysfunction in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618435/
https://www.ncbi.nlm.nih.gov/pubmed/28099427
http://dx.doi.org/10.1038/pr.2017.16
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