Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload

Antibody-drug conjugates (ADCs), designed to selectively deliver cytotoxic agents to antigen-bearing cells, are poised to become an important class of cancer therapeutics. Human epithelial growth factor receptor (HER2) is considered an effective target for cancer treatment, and a HER2-targeting ADC...

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Detalles Bibliográficos
Autores principales: Wang, Yanming, Fan, Shiyong, Zhong, Wu, Zhou, Xinbo, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618509/
https://www.ncbi.nlm.nih.gov/pubmed/28841157
http://dx.doi.org/10.3390/ijms18091860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618509/
https://www.ncbi.nlm.nih.gov/pubmed/28841157
http://dx.doi.org/10.3390/ijms18091860

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