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“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer
Sphingosine kinase (SphK) is a lipid enzyme that maintains cellular lipid homeostasis. Two SphK isozymes, SphK1 and SphK2, are expressed from different chromosomes and several variant isoforms are expressed from each of the isozymes, allowing for the multi-faceted biological diversity of SphK activi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618540/ https://www.ncbi.nlm.nih.gov/pubmed/28869494 http://dx.doi.org/10.3390/ijms18091891 |
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author | Haddadi, Nahal Lin, Yiguang Simpson, Ann M. Nassif, Najah T. McGowan, Eileen M. |
author_facet | Haddadi, Nahal Lin, Yiguang Simpson, Ann M. Nassif, Najah T. McGowan, Eileen M. |
author_sort | Haddadi, Nahal |
collection | PubMed |
description | Sphingosine kinase (SphK) is a lipid enzyme that maintains cellular lipid homeostasis. Two SphK isozymes, SphK1 and SphK2, are expressed from different chromosomes and several variant isoforms are expressed from each of the isozymes, allowing for the multi-faceted biological diversity of SphK activity. Historically, SphK1 is mainly associated with oncogenicity, however in reality, both SphK1 and SphK2 isozymes possess oncogenic properties and are recognized therapeutic targets. The absence of mutations of SphK in various cancer types has led to the theory that cancer cells develop a dependency on SphK signaling (hyper-SphK signaling) or “non-oncogenic addiction”. Here we discuss additional theories of SphK cellular mislocation and aberrant “dicing and splicing” as contributors to cancer cell biology and as key determinants of the success or failure of SphK/S1P (sphingosine 1 phosphate) based therapeutics. |
format | Online Article Text |
id | pubmed-5618540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56185402017-09-30 “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer Haddadi, Nahal Lin, Yiguang Simpson, Ann M. Nassif, Najah T. McGowan, Eileen M. Int J Mol Sci Review Sphingosine kinase (SphK) is a lipid enzyme that maintains cellular lipid homeostasis. Two SphK isozymes, SphK1 and SphK2, are expressed from different chromosomes and several variant isoforms are expressed from each of the isozymes, allowing for the multi-faceted biological diversity of SphK activity. Historically, SphK1 is mainly associated with oncogenicity, however in reality, both SphK1 and SphK2 isozymes possess oncogenic properties and are recognized therapeutic targets. The absence of mutations of SphK in various cancer types has led to the theory that cancer cells develop a dependency on SphK signaling (hyper-SphK signaling) or “non-oncogenic addiction”. Here we discuss additional theories of SphK cellular mislocation and aberrant “dicing and splicing” as contributors to cancer cell biology and as key determinants of the success or failure of SphK/S1P (sphingosine 1 phosphate) based therapeutics. MDPI 2017-09-02 /pmc/articles/PMC5618540/ /pubmed/28869494 http://dx.doi.org/10.3390/ijms18091891 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Haddadi, Nahal Lin, Yiguang Simpson, Ann M. Nassif, Najah T. McGowan, Eileen M. “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer |
title | “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer |
title_full | “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer |
title_fullStr | “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer |
title_full_unstemmed | “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer |
title_short | “Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer |
title_sort | “dicing and splicing” sphingosine kinase and relevance to cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618540/ https://www.ncbi.nlm.nih.gov/pubmed/28869494 http://dx.doi.org/10.3390/ijms18091891 |
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