Cargando…
“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer
Sphingosine kinase (SphK) is a lipid enzyme that maintains cellular lipid homeostasis. Two SphK isozymes, SphK1 and SphK2, are expressed from different chromosomes and several variant isoforms are expressed from each of the isozymes, allowing for the multi-faceted biological diversity of SphK activi...
Autores principales: | Haddadi, Nahal, Lin, Yiguang, Simpson, Ann M., Nassif, Najah T., McGowan, Eileen M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618540/ https://www.ncbi.nlm.nih.gov/pubmed/28869494 http://dx.doi.org/10.3390/ijms18091891 |
Ejemplares similares
-
Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
por: Hatoum, Diana, et al.
Publicado: (2017) -
Expression Profile of Sphingosine Kinase 1 Isoforms in Human Cancer Tissues and Cells: Importance and Clinical Relevance of the Neglected 1b-Isoform
por: Chen, Hongjie, et al.
Publicado: (2022) -
Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19
por: McGowan, Eileen M, et al.
Publicado: (2020) -
PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy
por: Haddadi, Nahal, et al.
Publicado: (2018) -
Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway
por: McGowan, Eileen M., et al.
Publicado: (2022)