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Intestinal and Circulating MicroRNAs in Coeliac Disease

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play a key role in the pathogenesis of autoimmune and gastrointestinal diseases. Previous studies have revealed that miRNAs are dysregulated in intestinal biopsies of patients affected by...

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Autores principales: Felli, Cristina, Baldassarre, Antonella, Masotti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618556/
https://www.ncbi.nlm.nih.gov/pubmed/28878141
http://dx.doi.org/10.3390/ijms18091907
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author Felli, Cristina
Baldassarre, Antonella
Masotti, Andrea
author_facet Felli, Cristina
Baldassarre, Antonella
Masotti, Andrea
author_sort Felli, Cristina
collection PubMed
description MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play a key role in the pathogenesis of autoimmune and gastrointestinal diseases. Previous studies have revealed that miRNAs are dysregulated in intestinal biopsies of patients affected by coeliac disease (CD). Combined bioinformatics analyses of miRNA expression profiles and mRNA target genes as classified by Gene Ontology, are powerful tools to investigate the functional role of miRNAs in coeliac disease. However, little is still known about the function of circulating miRNAs, their expression level compared to tissue miRNAs, and whether the mechanisms of post-transcriptional regulation are the same of tissue miRNAs. In any case, if we assume that a cell-cell communication process has to occur, and that circulating miRNAs are delivered to recipient cells, we can derive useful information by performing target predictions. Interestingly, all of the mRNA targets of dysregulated miRNAs reported in the literature (i.e., miR-31-5p, miR-192, miR-194, miR-449a and miR-638) belong to several important biological processes, such as Wnt signaling, cell proliferation and differentiation, and adherens junction pathways. Although we think that these predictions have to be necessarily confirmed by “wet-lab” data, the miRNAs dysregulated during the development of CD could be potentially involved in the pathogenesis of coeliac disease and their correlation with circulating miRNAs offers new possibilities to use them as disease biomarkers.
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spelling pubmed-56185562017-09-30 Intestinal and Circulating MicroRNAs in Coeliac Disease Felli, Cristina Baldassarre, Antonella Masotti, Andrea Int J Mol Sci Review MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play a key role in the pathogenesis of autoimmune and gastrointestinal diseases. Previous studies have revealed that miRNAs are dysregulated in intestinal biopsies of patients affected by coeliac disease (CD). Combined bioinformatics analyses of miRNA expression profiles and mRNA target genes as classified by Gene Ontology, are powerful tools to investigate the functional role of miRNAs in coeliac disease. However, little is still known about the function of circulating miRNAs, their expression level compared to tissue miRNAs, and whether the mechanisms of post-transcriptional regulation are the same of tissue miRNAs. In any case, if we assume that a cell-cell communication process has to occur, and that circulating miRNAs are delivered to recipient cells, we can derive useful information by performing target predictions. Interestingly, all of the mRNA targets of dysregulated miRNAs reported in the literature (i.e., miR-31-5p, miR-192, miR-194, miR-449a and miR-638) belong to several important biological processes, such as Wnt signaling, cell proliferation and differentiation, and adherens junction pathways. Although we think that these predictions have to be necessarily confirmed by “wet-lab” data, the miRNAs dysregulated during the development of CD could be potentially involved in the pathogenesis of coeliac disease and their correlation with circulating miRNAs offers new possibilities to use them as disease biomarkers. MDPI 2017-09-06 /pmc/articles/PMC5618556/ /pubmed/28878141 http://dx.doi.org/10.3390/ijms18091907 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Felli, Cristina
Baldassarre, Antonella
Masotti, Andrea
Intestinal and Circulating MicroRNAs in Coeliac Disease
title Intestinal and Circulating MicroRNAs in Coeliac Disease
title_full Intestinal and Circulating MicroRNAs in Coeliac Disease
title_fullStr Intestinal and Circulating MicroRNAs in Coeliac Disease
title_full_unstemmed Intestinal and Circulating MicroRNAs in Coeliac Disease
title_short Intestinal and Circulating MicroRNAs in Coeliac Disease
title_sort intestinal and circulating micrornas in coeliac disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618556/
https://www.ncbi.nlm.nih.gov/pubmed/28878141
http://dx.doi.org/10.3390/ijms18091907
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