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Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase

The liver toxicity of valproic acid (VPA) is an established side effect of this widely used antiepileptic drug, which is extremely problematic for patients with metabolic epilepsy and particularly epilepsy due to mitochondrial dysfunction. In the present report, we investigated the reason for liver...

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Detalles Bibliográficos
Autores principales:	Kudin, Alexei P., Mawasi, Hafiz, Eisenkraft, Arik, Elger, Christian E., Bialer, Meir, Kunz, Wolfram S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618561/ https://www.ncbi.nlm.nih.gov/pubmed/28878165 http://dx.doi.org/10.3390/ijms18091912

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