MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review

Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases...

Descripción completa

Detalles Bibliográficos
Autores principales: Smolle, Maria Anna, Leithner, Andreas, Posch, Florian, Szkandera, Joanna, Liegl-Atzwanger, Bernadette, Pichler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618609/
https://www.ncbi.nlm.nih.gov/pubmed/28895916
http://dx.doi.org/10.3390/ijms18091960
Descripción
Sumario:Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.

Ejemplares similares