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MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review

Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases...

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Autores principales: Smolle, Maria Anna, Leithner, Andreas, Posch, Florian, Szkandera, Joanna, Liegl-Atzwanger, Bernadette, Pichler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618609/
https://www.ncbi.nlm.nih.gov/pubmed/28895916
http://dx.doi.org/10.3390/ijms18091960
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author Smolle, Maria Anna
Leithner, Andreas
Posch, Florian
Szkandera, Joanna
Liegl-Atzwanger, Bernadette
Pichler, Martin
author_facet Smolle, Maria Anna
Leithner, Andreas
Posch, Florian
Szkandera, Joanna
Liegl-Atzwanger, Bernadette
Pichler, Martin
author_sort Smolle, Maria Anna
collection PubMed
description Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed.
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spelling pubmed-56186092017-09-30 MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review Smolle, Maria Anna Leithner, Andreas Posch, Florian Szkandera, Joanna Liegl-Atzwanger, Bernadette Pichler, Martin Int J Mol Sci Review Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed. MDPI 2017-09-12 /pmc/articles/PMC5618609/ /pubmed/28895916 http://dx.doi.org/10.3390/ijms18091960 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Smolle, Maria Anna
Leithner, Andreas
Posch, Florian
Szkandera, Joanna
Liegl-Atzwanger, Bernadette
Pichler, Martin
MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
title MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
title_full MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
title_fullStr MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
title_full_unstemmed MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
title_short MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
title_sort micrornas in different histologies of soft tissue sarcoma: a comprehensive review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618609/
https://www.ncbi.nlm.nih.gov/pubmed/28895916
http://dx.doi.org/10.3390/ijms18091960
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