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MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618609/ https://www.ncbi.nlm.nih.gov/pubmed/28895916 http://dx.doi.org/10.3390/ijms18091960 |
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author | Smolle, Maria Anna Leithner, Andreas Posch, Florian Szkandera, Joanna Liegl-Atzwanger, Bernadette Pichler, Martin |
author_facet | Smolle, Maria Anna Leithner, Andreas Posch, Florian Szkandera, Joanna Liegl-Atzwanger, Bernadette Pichler, Martin |
author_sort | Smolle, Maria Anna |
collection | PubMed |
description | Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed. |
format | Online Article Text |
id | pubmed-5618609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-56186092017-09-30 MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review Smolle, Maria Anna Leithner, Andreas Posch, Florian Szkandera, Joanna Liegl-Atzwanger, Bernadette Pichler, Martin Int J Mol Sci Review Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3’-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion. Therefore, the aim of the present review is to summarise current knowledge on the role of miRNAs in STS. Furthermore, the potential role of miRNAs as diagnostic, prognostic and predictive biomarkers is discussed. MDPI 2017-09-12 /pmc/articles/PMC5618609/ /pubmed/28895916 http://dx.doi.org/10.3390/ijms18091960 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Smolle, Maria Anna Leithner, Andreas Posch, Florian Szkandera, Joanna Liegl-Atzwanger, Bernadette Pichler, Martin MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review |
title | MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review |
title_full | MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review |
title_fullStr | MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review |
title_full_unstemmed | MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review |
title_short | MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review |
title_sort | micrornas in different histologies of soft tissue sarcoma: a comprehensive review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618609/ https://www.ncbi.nlm.nih.gov/pubmed/28895916 http://dx.doi.org/10.3390/ijms18091960 |
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