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Evolution of RAD- and DIV-Like Genes in Plants

Developmental genetic studies of Antirrhinum majus demonstrated that two transcription factors from the MYB gene family, RADIALIS (RAD) and DIVIRICATA (DIV), interact through antagonism to regulate floral dorsoventral asymmetry. Interestingly, similar antagonistic interaction found among proteins of...

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Autores principales: Gao, Ao, Zhang, Jingbo, Zhang, Wenheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618610/
https://www.ncbi.nlm.nih.gov/pubmed/28902138
http://dx.doi.org/10.3390/ijms18091961
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author Gao, Ao
Zhang, Jingbo
Zhang, Wenheng
author_facet Gao, Ao
Zhang, Jingbo
Zhang, Wenheng
author_sort Gao, Ao
collection PubMed
description Developmental genetic studies of Antirrhinum majus demonstrated that two transcription factors from the MYB gene family, RADIALIS (RAD) and DIVIRICATA (DIV), interact through antagonism to regulate floral dorsoventral asymmetry. Interestingly, similar antagonistic interaction found among proteins of FSM1 (RAD-like) and MYBI (DIV-like) in Solanum lycopersicum is involved in fruit development. Here, we report the reconstruction of the phylogeny of I-box-like and R-R-type clades, where RAD- and DIV-like genes belong, respectively. We also examined the homology of these antagonistic MYB proteins using these phylogenies. The results show that there are likely three paralogs of RAD-/I-box-like genes, RAD1, RAD2, and RAD3, which originated in the common ancestor of the core eudicots. In contrast, R-R-type sequences fall into two major clades, RR1 and RR2, the result of gene duplication in the common ancestor of both monocots and dicots. RR1 was divided into clades RR1A, RR1B, and RR1C, while RR2 was divided into clades RR2A/DIV1, RR2B/DIV2, and RR2C/DIV3. We demonstrate that among similar antagonistic interactions in An. Majus and So. lycopersicum, RAD-like genes originate from the RAD2 clade, while DIV-like genes originate from distantly related paralogs of the R-R-type lineage. The phylogenetic analyses of these two MYB clades lay the foundation for future comparative studies including testing the evolution of the antagonistic relationship of proteins.
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spelling pubmed-56186102017-09-30 Evolution of RAD- and DIV-Like Genes in Plants Gao, Ao Zhang, Jingbo Zhang, Wenheng Int J Mol Sci Article Developmental genetic studies of Antirrhinum majus demonstrated that two transcription factors from the MYB gene family, RADIALIS (RAD) and DIVIRICATA (DIV), interact through antagonism to regulate floral dorsoventral asymmetry. Interestingly, similar antagonistic interaction found among proteins of FSM1 (RAD-like) and MYBI (DIV-like) in Solanum lycopersicum is involved in fruit development. Here, we report the reconstruction of the phylogeny of I-box-like and R-R-type clades, where RAD- and DIV-like genes belong, respectively. We also examined the homology of these antagonistic MYB proteins using these phylogenies. The results show that there are likely three paralogs of RAD-/I-box-like genes, RAD1, RAD2, and RAD3, which originated in the common ancestor of the core eudicots. In contrast, R-R-type sequences fall into two major clades, RR1 and RR2, the result of gene duplication in the common ancestor of both monocots and dicots. RR1 was divided into clades RR1A, RR1B, and RR1C, while RR2 was divided into clades RR2A/DIV1, RR2B/DIV2, and RR2C/DIV3. We demonstrate that among similar antagonistic interactions in An. Majus and So. lycopersicum, RAD-like genes originate from the RAD2 clade, while DIV-like genes originate from distantly related paralogs of the R-R-type lineage. The phylogenetic analyses of these two MYB clades lay the foundation for future comparative studies including testing the evolution of the antagonistic relationship of proteins. MDPI 2017-09-13 /pmc/articles/PMC5618610/ /pubmed/28902138 http://dx.doi.org/10.3390/ijms18091961 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gao, Ao
Zhang, Jingbo
Zhang, Wenheng
Evolution of RAD- and DIV-Like Genes in Plants
title Evolution of RAD- and DIV-Like Genes in Plants
title_full Evolution of RAD- and DIV-Like Genes in Plants
title_fullStr Evolution of RAD- and DIV-Like Genes in Plants
title_full_unstemmed Evolution of RAD- and DIV-Like Genes in Plants
title_short Evolution of RAD- and DIV-Like Genes in Plants
title_sort evolution of rad- and div-like genes in plants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618610/
https://www.ncbi.nlm.nih.gov/pubmed/28902138
http://dx.doi.org/10.3390/ijms18091961
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