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Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes

The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has sti...

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Detalles Bibliográficos
Autores principales: Jakobsen, Tim Holm, Tolker-Nielsen, Tim, Givskov, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618619/
https://www.ncbi.nlm.nih.gov/pubmed/28902153
http://dx.doi.org/10.3390/ijms18091970
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author Jakobsen, Tim Holm
Tolker-Nielsen, Tim
Givskov, Michael
author_facet Jakobsen, Tim Holm
Tolker-Nielsen, Tim
Givskov, Michael
author_sort Jakobsen, Tim Holm
collection PubMed
description The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has still not been invented and/or developed any simple, efficient and reliable methods with which to “chemically” eradicate biofilm infections. This underlines the resilience of infective agents present as biofilms and it further emphasizes the insufficiency of today’s approaches used to combat chronic infections. A potential method for biofilm dismantling is chemical interception of regulatory processes that are specifically involved in the biofilm mode of life. In particular, bacterial cell to cell signaling called “Quorum Sensing” together with intracellular signaling by bis-(3′-5′)-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. More recently, regulatory processes governed by two component regulatory systems and small non-coding RNAs have been increasingly investigated. Here, we review novel findings and potentials of using small molecules to target and modulate these regulatory processes in the bacterium Pseudomonas aeruginosa to decrease its pathogenic potential.
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spelling pubmed-56186192017-09-30 Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes Jakobsen, Tim Holm Tolker-Nielsen, Tim Givskov, Michael Int J Mol Sci Review The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has still not been invented and/or developed any simple, efficient and reliable methods with which to “chemically” eradicate biofilm infections. This underlines the resilience of infective agents present as biofilms and it further emphasizes the insufficiency of today’s approaches used to combat chronic infections. A potential method for biofilm dismantling is chemical interception of regulatory processes that are specifically involved in the biofilm mode of life. In particular, bacterial cell to cell signaling called “Quorum Sensing” together with intracellular signaling by bis-(3′-5′)-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. More recently, regulatory processes governed by two component regulatory systems and small non-coding RNAs have been increasingly investigated. Here, we review novel findings and potentials of using small molecules to target and modulate these regulatory processes in the bacterium Pseudomonas aeruginosa to decrease its pathogenic potential. MDPI 2017-09-13 /pmc/articles/PMC5618619/ /pubmed/28902153 http://dx.doi.org/10.3390/ijms18091970 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jakobsen, Tim Holm
Tolker-Nielsen, Tim
Givskov, Michael
Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
title Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
title_full Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
title_fullStr Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
title_full_unstemmed Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
title_short Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
title_sort bacterial biofilm control by perturbation of bacterial signaling processes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618619/
https://www.ncbi.nlm.nih.gov/pubmed/28902153
http://dx.doi.org/10.3390/ijms18091970
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