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Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic mul...

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Autores principales: Gümbel, Denis, Bekeschus, Sander, Gelbrich, Nadine, Napp, Matthias, Ekkernkamp, Axel, Kramer, Axel, Stope, Matthias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618653/
https://www.ncbi.nlm.nih.gov/pubmed/28925941
http://dx.doi.org/10.3390/ijms18092004
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author Gümbel, Denis
Bekeschus, Sander
Gelbrich, Nadine
Napp, Matthias
Ekkernkamp, Axel
Kramer, Axel
Stope, Matthias B.
author_facet Gümbel, Denis
Bekeschus, Sander
Gelbrich, Nadine
Napp, Matthias
Ekkernkamp, Axel
Kramer, Axel
Stope, Matthias B.
author_sort Gümbel, Denis
collection PubMed
description Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles. Cold atmospheric plasma (CAP), a highly reactive (partially) ionized physical state, has been shown to inherit a significant anticancer capacity, leading to a new field in medicine called “plasma oncology.” The current article summarizes the potential of CAP in the treatment of human OS and reviews the underlying molecular mode of action.
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spelling pubmed-56186532017-09-30 Cold Atmospheric Plasma in the Treatment of Osteosarcoma Gümbel, Denis Bekeschus, Sander Gelbrich, Nadine Napp, Matthias Ekkernkamp, Axel Kramer, Axel Stope, Matthias B. Int J Mol Sci Review Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles. Cold atmospheric plasma (CAP), a highly reactive (partially) ionized physical state, has been shown to inherit a significant anticancer capacity, leading to a new field in medicine called “plasma oncology.” The current article summarizes the potential of CAP in the treatment of human OS and reviews the underlying molecular mode of action. MDPI 2017-09-19 /pmc/articles/PMC5618653/ /pubmed/28925941 http://dx.doi.org/10.3390/ijms18092004 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gümbel, Denis
Bekeschus, Sander
Gelbrich, Nadine
Napp, Matthias
Ekkernkamp, Axel
Kramer, Axel
Stope, Matthias B.
Cold Atmospheric Plasma in the Treatment of Osteosarcoma
title Cold Atmospheric Plasma in the Treatment of Osteosarcoma
title_full Cold Atmospheric Plasma in the Treatment of Osteosarcoma
title_fullStr Cold Atmospheric Plasma in the Treatment of Osteosarcoma
title_full_unstemmed Cold Atmospheric Plasma in the Treatment of Osteosarcoma
title_short Cold Atmospheric Plasma in the Treatment of Osteosarcoma
title_sort cold atmospheric plasma in the treatment of osteosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618653/
https://www.ncbi.nlm.nih.gov/pubmed/28925941
http://dx.doi.org/10.3390/ijms18092004
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