p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation

We previously reported that three point mutations in SASH1 and mutated SASH1 promote melanocyte migration in dyschromatosis universalis hereditaria (DUH) and a novel p53/POMC/Gαs/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phen...

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Detalles Bibliográficos
Autores principales: Zhou, Ding'an, Kuang, Zhongshu, Zeng, Xing, Wang, Ke, Ma, Jiangshu, Luo, Huangchao, Chen, Mei, Li, Yan, Zeng, Jiawei, Li, Shu, Luan, Fujun, He, Yong, Dai, Hongying, Liu, Beizhong, Li, Hui, He, Lin, Xing, Qinghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618682/
https://www.ncbi.nlm.nih.gov/pubmed/28382689
http://dx.doi.org/10.1111/jcmm.13168

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