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Paradoxical gain‐of‐function mutant of the G‐protein‐coupled receptor PROKR2 promotes early puberty

The human genome encodes ~750 G‐protein‐coupled receptors (GPCRs), including prokineticin receptor 2 (PROKR2) involved in the regulation of sexual maturation. Previously reported pathogenic gain‐of‐function mutations of GPCR genes invariably encoded aberrant receptors with excessive signal transduct...

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Detalles Bibliográficos
Autores principales:	Fukami, Maki, Suzuki, Erina, Izumi, Yoko, Torii, Tomohiro, Narumi, Satoshi, Igarashi, Maki, Miyado, Mami, Katsumi, Momori, Fujisawa, Yasuko, Nakabayashi, Kazuhiko, Hata, Kenichiro, Umezawa, Akihiro, Matsubara, Yoichi, Yamauchi, Junji, Ogata, Tsutomu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Short Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618689/ https://www.ncbi.nlm.nih.gov/pubmed/28338294 http://dx.doi.org/10.1111/jcmm.13146

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