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Class III antiarrhythmic drugs amiodarone and dronedarone impair K(IR)2.1 backward trafficking

Drug‐induced ion channel trafficking disturbance can cause cardiac arrhythmias. The subcellular level at which drugs interfere in trafficking pathways is largely unknown. K(IR)2.1 inward rectifier channels, largely responsible for the cardiac inward rectifier current (I(K) (1)), are degraded in lyso...

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Detalles Bibliográficos
Autores principales:	Ji, Yuan, Takanari, Hiroki, Qile, Muge, Nalos, Lukas, Houtman, Marien J.C., Romunde, Fee L., Heukers, Raimond, van Bergen en Henegouwen, Paul M.P., Vos, Marc A., van der Heyden, Marcel A.G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618701/ https://www.ncbi.nlm.nih.gov/pubmed/28425222 http://dx.doi.org/10.1111/jcmm.13172

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