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Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass

BACKGROUND: Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC) of cervix that presented with an anterior chest wall mass. CASE: A 43-year-old Hispanic female presented with a two-month histor...

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Autores principales: Karapetyan, Lilit, Rai, Manoj, Dawani, Om, Laird-Fick, Heather S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618741/
https://www.ncbi.nlm.nih.gov/pubmed/29062577
http://dx.doi.org/10.1155/2017/5264564
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author Karapetyan, Lilit
Rai, Manoj
Dawani, Om
Laird-Fick, Heather S.
author_facet Karapetyan, Lilit
Rai, Manoj
Dawani, Om
Laird-Fick, Heather S.
author_sort Karapetyan, Lilit
collection PubMed
description BACKGROUND: Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC) of cervix that presented with an anterior chest wall mass. CASE: A 43-year-old Hispanic female presented with a two-month history of a central chest wall mass. The patient's only past medical history was SSCC of the cervix, stage IIB, diagnosed two years priorly. She underwent neoadjuvant chemoradiation therapy (CRT) with cisplatin followed by radical hysterectomy. Surgical margins were positive which led to adjuvant CRT with carboplatin and paclitaxel. PET scan 4 months after the postoperative treatment was negative for recurrence and metastatic disease. On current presentation, the CT chest revealed anterior mediastinal destructive soft tissue mass involving sternum, and the biopsy showed SSCC. The patient received palliative radiation therapy to her chest with improvement in pain and ability to swallow. After discussing the prognosis she refused further chemotherapy and decided on hospice care. CONCLUSION: Despite good response to first-line therapy, SSCC tends to recur early and does not respond to second-line therapy. Radiation therapy seems to be the most effective modality for treatment, but randomized controlled trials of therapy are impractical.
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spelling pubmed-56187412017-10-23 Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass Karapetyan, Lilit Rai, Manoj Dawani, Om Laird-Fick, Heather S. Case Rep Oncol Med Case Report BACKGROUND: Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer. We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC) of cervix that presented with an anterior chest wall mass. CASE: A 43-year-old Hispanic female presented with a two-month history of a central chest wall mass. The patient's only past medical history was SSCC of the cervix, stage IIB, diagnosed two years priorly. She underwent neoadjuvant chemoradiation therapy (CRT) with cisplatin followed by radical hysterectomy. Surgical margins were positive which led to adjuvant CRT with carboplatin and paclitaxel. PET scan 4 months after the postoperative treatment was negative for recurrence and metastatic disease. On current presentation, the CT chest revealed anterior mediastinal destructive soft tissue mass involving sternum, and the biopsy showed SSCC. The patient received palliative radiation therapy to her chest with improvement in pain and ability to swallow. After discussing the prognosis she refused further chemotherapy and decided on hospice care. CONCLUSION: Despite good response to first-line therapy, SSCC tends to recur early and does not respond to second-line therapy. Radiation therapy seems to be the most effective modality for treatment, but randomized controlled trials of therapy are impractical. Hindawi 2017 2017-09-14 /pmc/articles/PMC5618741/ /pubmed/29062577 http://dx.doi.org/10.1155/2017/5264564 Text en Copyright © 2017 Lilit Karapetyan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Karapetyan, Lilit
Rai, Manoj
Dawani, Om
Laird-Fick, Heather S.
Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass
title Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass
title_full Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass
title_fullStr Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass
title_full_unstemmed Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass
title_short Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass
title_sort metastatic sarcomatoid squamous cell carcinoma of the cervix presenting with chest mass
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618741/
https://www.ncbi.nlm.nih.gov/pubmed/29062577
http://dx.doi.org/10.1155/2017/5264564
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