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Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618754/ https://www.ncbi.nlm.nih.gov/pubmed/29062840 http://dx.doi.org/10.1155/2017/5307523 |
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author | Oka, Rie Shibata, Kyoko Sakurai, Masaru Kometani, Mitsuhiro Yamagishi, Masakazu Yoshimura, Kenichi Yoneda, Takashi |
author_facet | Oka, Rie Shibata, Kyoko Sakurai, Masaru Kometani, Mitsuhiro Yamagishi, Masakazu Yoshimura, Kenichi Yoneda, Takashi |
author_sort | Oka, Rie |
collection | PubMed |
description | We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes. |
format | Online Article Text |
id | pubmed-5618754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56187542017-10-23 Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults Oka, Rie Shibata, Kyoko Sakurai, Masaru Kometani, Mitsuhiro Yamagishi, Masakazu Yoshimura, Kenichi Yoneda, Takashi J Diabetes Res Research Article We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes. Hindawi 2017 2017-09-14 /pmc/articles/PMC5618754/ /pubmed/29062840 http://dx.doi.org/10.1155/2017/5307523 Text en Copyright © 2017 Rie Oka et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Oka, Rie Shibata, Kyoko Sakurai, Masaru Kometani, Mitsuhiro Yamagishi, Masakazu Yoshimura, Kenichi Yoneda, Takashi Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
title | Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
title_full | Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
title_fullStr | Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
title_full_unstemmed | Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
title_short | Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults |
title_sort | trajectories of postload plasma glucose in the development of type 2 diabetes in japanese adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618754/ https://www.ncbi.nlm.nih.gov/pubmed/29062840 http://dx.doi.org/10.1155/2017/5307523 |
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