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Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults

We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the...

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Autores principales: Oka, Rie, Shibata, Kyoko, Sakurai, Masaru, Kometani, Mitsuhiro, Yamagishi, Masakazu, Yoshimura, Kenichi, Yoneda, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618754/
https://www.ncbi.nlm.nih.gov/pubmed/29062840
http://dx.doi.org/10.1155/2017/5307523
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author Oka, Rie
Shibata, Kyoko
Sakurai, Masaru
Kometani, Mitsuhiro
Yamagishi, Masakazu
Yoshimura, Kenichi
Yoneda, Takashi
author_facet Oka, Rie
Shibata, Kyoko
Sakurai, Masaru
Kometani, Mitsuhiro
Yamagishi, Masakazu
Yoshimura, Kenichi
Yoneda, Takashi
author_sort Oka, Rie
collection PubMed
description We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes.
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spelling pubmed-56187542017-10-23 Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults Oka, Rie Shibata, Kyoko Sakurai, Masaru Kometani, Mitsuhiro Yamagishi, Masakazu Yoshimura, Kenichi Yoneda, Takashi J Diabetes Res Research Article We aimed to clarify how the trajectories of 1-hour postload plasma glucose (PG) and 2-hour PG were different in the development of type 2 diabetes. Using data of repeated health checkups in Japanese workers from April 2006 to March 2016, longitudinal changes of fasting, 1-hour, and 2-hour PG on the oral glucose tolerance test were analyzed with a linear mixed effects model. Of the 1464 nondiabetic subjects at baseline, 112 subjects progressed to type 2 diabetes during the observation period (progressors). In progressors, 1-hour PG and 2-hour PG showed gradual increases with slopes of 1.33 ± 0.2 and 0.58 ± 0.2 mg/dL/year, respectively, followed by a steep increase by which they attained diabetes. Until immediately before the diabetes transition, age- and sex-adjusted mean level of 2-hour PG was 149 ± 2.7 mg/dL, 34 ± 2.7 (30%) higher compared to nonprogressors, while that of 1-hour PG was 206 ± 4.1 mg/dL, 60 ± 4.3 mg/dL (41%) higher compared to nonprogressors. In conclusion, diabetes transition was preceded by a mild elevation of 2-hour PG for several years or more. The elevation in 1-hour PG was larger than that of 2-hour PG until immediately before the transition to diabetes. Hindawi 2017 2017-09-14 /pmc/articles/PMC5618754/ /pubmed/29062840 http://dx.doi.org/10.1155/2017/5307523 Text en Copyright © 2017 Rie Oka et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Oka, Rie
Shibata, Kyoko
Sakurai, Masaru
Kometani, Mitsuhiro
Yamagishi, Masakazu
Yoshimura, Kenichi
Yoneda, Takashi
Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
title Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
title_full Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
title_fullStr Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
title_full_unstemmed Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
title_short Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults
title_sort trajectories of postload plasma glucose in the development of type 2 diabetes in japanese adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618754/
https://www.ncbi.nlm.nih.gov/pubmed/29062840
http://dx.doi.org/10.1155/2017/5307523
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