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BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child

One 2-year-old undernourished girl presented to our outpatient with large erythematous scaly plaques in arm along with multiple bony swellings over nose, fingers, left foot, and back for the past 1 year. Apart from skin and bone lesions the girl was also had intermittent fever, pallor, irritability,...

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Autores principales: De, Abhishek, Sarkar, Sumantra, Sharma, Nidhi, Ansari, Asad, Reja, Abu Hena Hasanoor, Sarda, Aarti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618842/
https://www.ncbi.nlm.nih.gov/pubmed/28979017
http://dx.doi.org/10.4103/ijd.IJD_55_17
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author De, Abhishek
Sarkar, Sumantra
Sharma, Nidhi
Ansari, Asad
Reja, Abu Hena Hasanoor
Sarda, Aarti
author_facet De, Abhishek
Sarkar, Sumantra
Sharma, Nidhi
Ansari, Asad
Reja, Abu Hena Hasanoor
Sarda, Aarti
author_sort De, Abhishek
collection PubMed
description One 2-year-old undernourished girl presented to our outpatient with large erythematous scaly plaques in arm along with multiple bony swellings over nose, fingers, left foot, and back for the past 1 year. Apart from skin and bone lesions the girl was also had intermittent fever, pallor, irritability, and malnourishment. Her parents gave a history of incomplete healing at the BCG vaccination site. The case was diagnosed to be case of disseminated mycobacterial infection skin and bone with the help of histopathology, radiological examination, and DNA polymerase chain reaction (PCR). DNA PCR from the skin lesion came positive for mycobacteria tuberculosis complex. The girl was treated with 6 months of standard antitubercular drug treatment with very good improvement not only of her cutaneous and bone changes but also of her general health and growth. We report the case because paucity of similar infection in literature and for greater recognition of potential epidemiological threat.
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spelling pubmed-56188422017-10-04 BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child De, Abhishek Sarkar, Sumantra Sharma, Nidhi Ansari, Asad Reja, Abu Hena Hasanoor Sarda, Aarti Indian J Dermatol Case Report One 2-year-old undernourished girl presented to our outpatient with large erythematous scaly plaques in arm along with multiple bony swellings over nose, fingers, left foot, and back for the past 1 year. Apart from skin and bone lesions the girl was also had intermittent fever, pallor, irritability, and malnourishment. Her parents gave a history of incomplete healing at the BCG vaccination site. The case was diagnosed to be case of disseminated mycobacterial infection skin and bone with the help of histopathology, radiological examination, and DNA polymerase chain reaction (PCR). DNA PCR from the skin lesion came positive for mycobacteria tuberculosis complex. The girl was treated with 6 months of standard antitubercular drug treatment with very good improvement not only of her cutaneous and bone changes but also of her general health and growth. We report the case because paucity of similar infection in literature and for greater recognition of potential epidemiological threat. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5618842/ /pubmed/28979017 http://dx.doi.org/10.4103/ijd.IJD_55_17 Text en Copyright: © 2017 Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
De, Abhishek
Sarkar, Sumantra
Sharma, Nidhi
Ansari, Asad
Reja, Abu Hena Hasanoor
Sarda, Aarti
BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child
title BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child
title_full BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child
title_fullStr BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child
title_full_unstemmed BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child
title_short BCG-induced Disseminated Mycobacterial Infection of Skin and Bone in an Otherwise Immunocompetent Child
title_sort bcg-induced disseminated mycobacterial infection of skin and bone in an otherwise immunocompetent child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618842/
https://www.ncbi.nlm.nih.gov/pubmed/28979017
http://dx.doi.org/10.4103/ijd.IJD_55_17
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