County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels

AIM: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvest...

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Autores principales: Oancea, S Cristina, Rundquist, Bradley C, Simon, Isaac, Swartz, Sami, Zheng, Yun, Zhou, Xudong, Sens, Mary Ann, Schwartz, Gary G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618932/
https://www.ncbi.nlm.nih.gov/pubmed/28835109
http://dx.doi.org/10.2217/fon-2017-0165
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author Oancea, S Cristina
Rundquist, Bradley C
Simon, Isaac
Swartz, Sami
Zheng, Yun
Zhou, Xudong
Sens, Mary Ann
Schwartz, Gary G
author_facet Oancea, S Cristina
Rundquist, Bradley C
Simon, Isaac
Swartz, Sami
Zheng, Yun
Zhou, Xudong
Sens, Mary Ann
Schwartz, Gary G
author_sort Oancea, S Cristina
collection PubMed
description AIM: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level. METHODS: We examined the relationships between CLL and RR per county in 478 counties with publicly-available data. RESULTS: After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001). CONCLUSION: CLL is significantly associated with RR at the county level.
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spelling pubmed-56189322018-09-01 County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels Oancea, S Cristina Rundquist, Bradley C Simon, Isaac Swartz, Sami Zheng, Yun Zhou, Xudong Sens, Mary Ann Schwartz, Gary G Future Oncol Research Article AIM: We previously reported that incidence rates for chronic lymphocytic leukemia (CLL) among US states are significantly correlated with levels of residential radon (RR). Because these correlations could be influenced by confounding and/or misclassification among large geographic units, we reinvestigated them using smaller geographic units that better reflect exposure and disease at the individual level. METHODS: We examined the relationships between CLL and RR per county in 478 counties with publicly-available data. RESULTS: After adjustment for ultraviolet radiation, a possible risk factor for CLL, county rates for CLL and RR were significantly correlated among males and females both together and separately (p < 0.0001). CONCLUSION: CLL is significantly associated with RR at the county level. Future Medicine Ltd 2017-09 2017-08-24 /pmc/articles/PMC5618932/ /pubmed/28835109 http://dx.doi.org/10.2217/fon-2017-0165 Text en © 2017 S. Cristina Oancea for Gary G. Schwartz This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Oancea, S Cristina
Rundquist, Bradley C
Simon, Isaac
Swartz, Sami
Zheng, Yun
Zhou, Xudong
Sens, Mary Ann
Schwartz, Gary G
County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
title County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
title_full County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
title_fullStr County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
title_full_unstemmed County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
title_short County level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
title_sort county level incidence rates of chronic lymphocytic leukemia are associated with residential radon levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618932/
https://www.ncbi.nlm.nih.gov/pubmed/28835109
http://dx.doi.org/10.2217/fon-2017-0165
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