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Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report

Cognitive deficits in cancer patients can be related to depression, anxiety, and the side effects of treatments such as fatigue. In this case report, we described an elderly patient with rectal adenocarcinoma, which presented depressive symptoms and memory complaints after treatment with 5-Fluoracil...

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Autores principales: Bottino, Sara Mota Borges, Garcia, Célia Petrossi Gallo, Viana, Bernardo de Mattos, Bottino, Cássio Machado de Campos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619204/
https://www.ncbi.nlm.nih.gov/pubmed/29213856
http://dx.doi.org/10.1590/S1980-57642013DN70300013
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author Bottino, Sara Mota Borges
Garcia, Célia Petrossi Gallo
Viana, Bernardo de Mattos
Bottino, Cássio Machado de Campos
author_facet Bottino, Sara Mota Borges
Garcia, Célia Petrossi Gallo
Viana, Bernardo de Mattos
Bottino, Cássio Machado de Campos
author_sort Bottino, Sara Mota Borges
collection PubMed
description Cognitive deficits in cancer patients can be related to depression, anxiety, and the side effects of treatments such as fatigue. In this case report, we described an elderly patient with rectal adenocarcinoma, which presented depressive symptoms and memory complaints after treatment with 5-Fluoracil and Leucovorin. Depressive symptoms improved after two months but cognitive and functional impairment worsened suggesting the diagnosis of mild dementia. Structural and functional brain changes were seen on neuroimaging exams. Rivastigmine was introduced up to 12 mg/day, and after a one-year follow up the patient remained stable. Cognitive deficits can be a consequence of cancer therapies and a protocol to investigate deficits cognitive could be useful to the diferential diagnosis and management of elderly cancer patients submitted to chemotherapy.
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spelling pubmed-56192042017-12-06 Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report Bottino, Sara Mota Borges Garcia, Célia Petrossi Gallo Viana, Bernardo de Mattos Bottino, Cássio Machado de Campos Dement Neuropsychol Case Reports Cognitive deficits in cancer patients can be related to depression, anxiety, and the side effects of treatments such as fatigue. In this case report, we described an elderly patient with rectal adenocarcinoma, which presented depressive symptoms and memory complaints after treatment with 5-Fluoracil and Leucovorin. Depressive symptoms improved after two months but cognitive and functional impairment worsened suggesting the diagnosis of mild dementia. Structural and functional brain changes were seen on neuroimaging exams. Rivastigmine was introduced up to 12 mg/day, and after a one-year follow up the patient remained stable. Cognitive deficits can be a consequence of cancer therapies and a protocol to investigate deficits cognitive could be useful to the diferential diagnosis and management of elderly cancer patients submitted to chemotherapy. Associação de Neurologia Cognitiva e do Comportamento 2013 /pmc/articles/PMC5619204/ /pubmed/29213856 http://dx.doi.org/10.1590/S1980-57642013DN70300013 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Bottino, Sara Mota Borges
Garcia, Célia Petrossi Gallo
Viana, Bernardo de Mattos
Bottino, Cássio Machado de Campos
Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report
title Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report
title_full Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report
title_fullStr Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report
title_full_unstemmed Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report
title_short Depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-Fluoracil: a case report
title_sort depressive symptoms and cognitive deficits in a cancer patient submitted to chemotherapy with 5-fluoracil: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619204/
https://www.ncbi.nlm.nih.gov/pubmed/29213856
http://dx.doi.org/10.1590/S1980-57642013DN70300013
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