PET and the multitracer concept in the study of neurodegenerative diseases

The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo, anatomopathological changes involved in the development of different clinical sympt...

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Detalles Bibliográficos
Autores principales: Engler, Henry, Damian, Andres, Bentancourt, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2015
Materias:
Views & Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619316/
https://www.ncbi.nlm.nih.gov/pubmed/29213983
http://dx.doi.org/10.1590/1980-57642015DN94000343
Descripción
Sumario:The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo, anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of (18)F-flourodeoxyglucose (FDG) and N-[(11)C-methyl]-L-deuterodeprenyl (DED), FDG and N-[(11)C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[(11)C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [(15)O]H2O.

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