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Cognitive impairment in patients with clinically isolated syndrome
Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Neurologia Cognitiva e do
Comportamento
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619339/ https://www.ncbi.nlm.nih.gov/pubmed/29213807 http://dx.doi.org/10.1590/S1980-57642012DN06040011 |
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author | Anhoque, Carolina Fiorin Biccas Neto, Laurentino Domingues, Simone Cristina Aires Teixeira, Antônio Lúcio Domingues, Renan Barros |
author_facet | Anhoque, Carolina Fiorin Biccas Neto, Laurentino Domingues, Simone Cristina Aires Teixeira, Antônio Lúcio Domingues, Renan Barros |
author_sort | Anhoque, Carolina Fiorin |
collection | PubMed |
description | Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning. |
format | Online Article Text |
id | pubmed-5619339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Associação de Neurologia Cognitiva e do
Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-56193392017-12-06 Cognitive impairment in patients with clinically isolated syndrome Anhoque, Carolina Fiorin Biccas Neto, Laurentino Domingues, Simone Cristina Aires Teixeira, Antônio Lúcio Domingues, Renan Barros Dement Neuropsychol Original Articles Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning. Associação de Neurologia Cognitiva e do Comportamento 2012 /pmc/articles/PMC5619339/ /pubmed/29213807 http://dx.doi.org/10.1590/S1980-57642012DN06040011 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Anhoque, Carolina Fiorin Biccas Neto, Laurentino Domingues, Simone Cristina Aires Teixeira, Antônio Lúcio Domingues, Renan Barros Cognitive impairment in patients with clinically isolated syndrome |
title | Cognitive impairment in patients with clinically isolated
syndrome |
title_full | Cognitive impairment in patients with clinically isolated
syndrome |
title_fullStr | Cognitive impairment in patients with clinically isolated
syndrome |
title_full_unstemmed | Cognitive impairment in patients with clinically isolated
syndrome |
title_short | Cognitive impairment in patients with clinically isolated
syndrome |
title_sort | cognitive impairment in patients with clinically isolated
syndrome |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619339/ https://www.ncbi.nlm.nih.gov/pubmed/29213807 http://dx.doi.org/10.1590/S1980-57642012DN06040011 |
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