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Cognitive impairment in patients with clinically isolated syndrome

Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy s...

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Autores principales: Anhoque, Carolina Fiorin, Biccas Neto, Laurentino, Domingues, Simone Cristina Aires, Teixeira, Antônio Lúcio, Domingues, Renan Barros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619339/
https://www.ncbi.nlm.nih.gov/pubmed/29213807
http://dx.doi.org/10.1590/S1980-57642012DN06040011
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author Anhoque, Carolina Fiorin
Biccas Neto, Laurentino
Domingues, Simone Cristina Aires
Teixeira, Antônio Lúcio
Domingues, Renan Barros
author_facet Anhoque, Carolina Fiorin
Biccas Neto, Laurentino
Domingues, Simone Cristina Aires
Teixeira, Antônio Lúcio
Domingues, Renan Barros
author_sort Anhoque, Carolina Fiorin
collection PubMed
description Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning.
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spelling pubmed-56193392017-12-06 Cognitive impairment in patients with clinically isolated syndrome Anhoque, Carolina Fiorin Biccas Neto, Laurentino Domingues, Simone Cristina Aires Teixeira, Antônio Lúcio Domingues, Renan Barros Dement Neuropsychol Original Articles Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). OBJECTIVE: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. METHODS: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. RESULTS: CIS patients had significantly worse performance on the Paced Auditory Serial Addition Test (PASAT) 2 seconds (P=0.009) and on verbal fluency tests (P=0.0038) than controls. CONCLUSION: CIS patients had worse cognitive performance than controls on neuropsychological tests evaluating executive functioning. Associação de Neurologia Cognitiva e do Comportamento 2012 /pmc/articles/PMC5619339/ /pubmed/29213807 http://dx.doi.org/10.1590/S1980-57642012DN06040011 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Anhoque, Carolina Fiorin
Biccas Neto, Laurentino
Domingues, Simone Cristina Aires
Teixeira, Antônio Lúcio
Domingues, Renan Barros
Cognitive impairment in patients with clinically isolated syndrome
title Cognitive impairment in patients with clinically isolated syndrome
title_full Cognitive impairment in patients with clinically isolated syndrome
title_fullStr Cognitive impairment in patients with clinically isolated syndrome
title_full_unstemmed Cognitive impairment in patients with clinically isolated syndrome
title_short Cognitive impairment in patients with clinically isolated syndrome
title_sort cognitive impairment in patients with clinically isolated syndrome
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619339/
https://www.ncbi.nlm.nih.gov/pubmed/29213807
http://dx.doi.org/10.1590/S1980-57642012DN06040011
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