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Factors associated with morphometric brain changes in cognitively normal aging

OBJECTIVE: Cognitive impairment is associated with reductions in brain weight and volume. The factors related to morphometric brain changes in cognitively normal aging remain unknown. We aimed to identify which clinical factors are associated with morphometric brain changes in cognitively normal agi...

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Autores principales: Ferretti-Rebustini, Renata Eloah de Lucena, Jacob-Filho, Wilson, Suemoto, Claudia Kimie, Farfel, José Marcelo, Leite, Renata Elaine Paraiso, Grinberg, Lea Tenenholz, Pasqualucci, Carlos Augusto, Nitrini, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619348/
https://www.ncbi.nlm.nih.gov/pubmed/29213951
http://dx.doi.org/10.1590/1980-57642015DN92000004
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author Ferretti-Rebustini, Renata Eloah de Lucena
Jacob-Filho, Wilson
Suemoto, Claudia Kimie
Farfel, José Marcelo
Leite, Renata Elaine Paraiso
Grinberg, Lea Tenenholz
Pasqualucci, Carlos Augusto
Nitrini, Ricardo
author_facet Ferretti-Rebustini, Renata Eloah de Lucena
Jacob-Filho, Wilson
Suemoto, Claudia Kimie
Farfel, José Marcelo
Leite, Renata Elaine Paraiso
Grinberg, Lea Tenenholz
Pasqualucci, Carlos Augusto
Nitrini, Ricardo
author_sort Ferretti-Rebustini, Renata Eloah de Lucena
collection PubMed
description OBJECTIVE: Cognitive impairment is associated with reductions in brain weight and volume. The factors related to morphometric brain changes in cognitively normal aging remain unknown. We aimed to identify which clinical factors are associated with morphometric brain changes in cognitively normal aging. METHODS: A cross-sectional study of 414 subjects, ≥50 years old submitted to clinical assessment and brain autopsy, after informed consent, was carried out at the São Paulo Autopsy Service, Brazil. Data on cognitive and functional evaluations were collected through structured interview applied to the next-of-kin. Brain weight (g) and volume (mL) measurements were obtained and adjusted for head circumference (cm). Associations between brain weight/volume and related factors were obtained through univariate and multivariate analysis. RESULTS: Participants were predominantly male (60.4%), Caucasian (69%), with mean age of 67.1 ± 10.9 years. Mean brain weight was 1219.2 ± 140.9 g, and mean brain volume was 1217.1 ± 152.3 mL. Head circumference was independently associated with low brain weight (p<0.001) and volume (p<0.001). Total and adjusted brain weight and volume decreased in some conditions. Female gender (p<0.001), hypertension (p<0.009), coronary artery disease (p<0.013) and walking assistance (p<0.011) were associated with lower adjusted brain weight while schooling was associated with higher adjusted brain weight (p<0.003). Female gender (p<0.001), age (p<0.001) and hypertension (p<0.011) were associated with low adjusted brain volume. CONCLUSION: Morphometric brain changes occur despite the absence of cognitive impairment and were predominantly associated with age, female gender, mobility impairment and cardiovascular conditions. Schooling may be a protective factor.
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spelling pubmed-56193482017-12-06 Factors associated with morphometric brain changes in cognitively normal aging Ferretti-Rebustini, Renata Eloah de Lucena Jacob-Filho, Wilson Suemoto, Claudia Kimie Farfel, José Marcelo Leite, Renata Elaine Paraiso Grinberg, Lea Tenenholz Pasqualucci, Carlos Augusto Nitrini, Ricardo Dement Neuropsychol Original Articles OBJECTIVE: Cognitive impairment is associated with reductions in brain weight and volume. The factors related to morphometric brain changes in cognitively normal aging remain unknown. We aimed to identify which clinical factors are associated with morphometric brain changes in cognitively normal aging. METHODS: A cross-sectional study of 414 subjects, ≥50 years old submitted to clinical assessment and brain autopsy, after informed consent, was carried out at the São Paulo Autopsy Service, Brazil. Data on cognitive and functional evaluations were collected through structured interview applied to the next-of-kin. Brain weight (g) and volume (mL) measurements were obtained and adjusted for head circumference (cm). Associations between brain weight/volume and related factors were obtained through univariate and multivariate analysis. RESULTS: Participants were predominantly male (60.4%), Caucasian (69%), with mean age of 67.1 ± 10.9 years. Mean brain weight was 1219.2 ± 140.9 g, and mean brain volume was 1217.1 ± 152.3 mL. Head circumference was independently associated with low brain weight (p<0.001) and volume (p<0.001). Total and adjusted brain weight and volume decreased in some conditions. Female gender (p<0.001), hypertension (p<0.009), coronary artery disease (p<0.013) and walking assistance (p<0.011) were associated with lower adjusted brain weight while schooling was associated with higher adjusted brain weight (p<0.003). Female gender (p<0.001), age (p<0.001) and hypertension (p<0.011) were associated with low adjusted brain volume. CONCLUSION: Morphometric brain changes occur despite the absence of cognitive impairment and were predominantly associated with age, female gender, mobility impairment and cardiovascular conditions. Schooling may be a protective factor. Associação de Neurologia Cognitiva e do Comportamento 2015 /pmc/articles/PMC5619348/ /pubmed/29213951 http://dx.doi.org/10.1590/1980-57642015DN92000004 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ferretti-Rebustini, Renata Eloah de Lucena
Jacob-Filho, Wilson
Suemoto, Claudia Kimie
Farfel, José Marcelo
Leite, Renata Elaine Paraiso
Grinberg, Lea Tenenholz
Pasqualucci, Carlos Augusto
Nitrini, Ricardo
Factors associated with morphometric brain changes in cognitively normal aging
title Factors associated with morphometric brain changes in cognitively normal aging
title_full Factors associated with morphometric brain changes in cognitively normal aging
title_fullStr Factors associated with morphometric brain changes in cognitively normal aging
title_full_unstemmed Factors associated with morphometric brain changes in cognitively normal aging
title_short Factors associated with morphometric brain changes in cognitively normal aging
title_sort factors associated with morphometric brain changes in cognitively normal aging
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619348/
https://www.ncbi.nlm.nih.gov/pubmed/29213951
http://dx.doi.org/10.1590/1980-57642015DN92000004
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