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Autoimmune limbic encephalitis: A manifestation of systemic lupus erythematosus in the central nervous system
Autoimmune limbic encephalitis (ALE) associated with systemic lupus erythematosus (SLE) is a rare entity with few reports in the literature to date. In general, ALE associated with SLE has a satisfactory response to immunosuppressive treatment (RIT), but the pathogenesis of this association is poorl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Neurologia Cognitiva e do
Comportamento
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619358/ https://www.ncbi.nlm.nih.gov/pubmed/29213961 http://dx.doi.org/10.1590/1980-57642015DN92000014 |
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author | Angst, Débora Bartzen Moraes de Figueiredo, Nathália Stela Visoná Passarelli, Valmir Baldocchi, Meire Argentoni Rocha, Maria Sheila Guimarães Brucki, Sonia Maria Dozzi |
author_facet | Angst, Débora Bartzen Moraes de Figueiredo, Nathália Stela Visoná Passarelli, Valmir Baldocchi, Meire Argentoni Rocha, Maria Sheila Guimarães Brucki, Sonia Maria Dozzi |
author_sort | Angst, Débora Bartzen Moraes |
collection | PubMed |
description | Autoimmune limbic encephalitis (ALE) associated with systemic lupus erythematosus (SLE) is a rare entity with few reports in the literature to date. In general, ALE associated with SLE has a satisfactory response to immunosuppressive treatment (RIT), but the pathogenesis of this association is poorly understood and may include an autoimmunity component. We report a case study describing the diagnosis and management of limbic encephalitis in a patient with active Systemic Lupus Erythematosus disease (SLE) and past medical history of cancer (endometrial adenocarcinoma in 2004 and papillary urothelial carcinoma in 2011 with curative treatment), followed over a one-year period. We discuss the possible association between limbic encephalitis and all past neoplastic and immune-mediated conditions of this patient. In this particularly case, autoimmunity was the most relevant factor associated with limbic encephalitis given negative neoplastic screening. Moreover, a good response was observed to immunotherapy, not seen with paraneoplastic limbic encephalitis, which is associated with poor response. In this case, the association of ALE with SLE is possible, since laboratory testing disclosed lupic activity and the patient had involvement of other systems (such as hematologic) during the period. However, the presence of other surface membrane antibodies are possible in the search for alternative etiologies. |
format | Online Article Text |
id | pubmed-5619358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Associação de Neurologia Cognitiva e do
Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-56193582017-12-06 Autoimmune limbic encephalitis: A manifestation of systemic lupus erythematosus in the central nervous system Angst, Débora Bartzen Moraes de Figueiredo, Nathália Stela Visoná Passarelli, Valmir Baldocchi, Meire Argentoni Rocha, Maria Sheila Guimarães Brucki, Sonia Maria Dozzi Dement Neuropsychol Case Report Autoimmune limbic encephalitis (ALE) associated with systemic lupus erythematosus (SLE) is a rare entity with few reports in the literature to date. In general, ALE associated with SLE has a satisfactory response to immunosuppressive treatment (RIT), but the pathogenesis of this association is poorly understood and may include an autoimmunity component. We report a case study describing the diagnosis and management of limbic encephalitis in a patient with active Systemic Lupus Erythematosus disease (SLE) and past medical history of cancer (endometrial adenocarcinoma in 2004 and papillary urothelial carcinoma in 2011 with curative treatment), followed over a one-year period. We discuss the possible association between limbic encephalitis and all past neoplastic and immune-mediated conditions of this patient. In this particularly case, autoimmunity was the most relevant factor associated with limbic encephalitis given negative neoplastic screening. Moreover, a good response was observed to immunotherapy, not seen with paraneoplastic limbic encephalitis, which is associated with poor response. In this case, the association of ALE with SLE is possible, since laboratory testing disclosed lupic activity and the patient had involvement of other systems (such as hematologic) during the period. However, the presence of other surface membrane antibodies are possible in the search for alternative etiologies. Associação de Neurologia Cognitiva e do Comportamento 2015 /pmc/articles/PMC5619358/ /pubmed/29213961 http://dx.doi.org/10.1590/1980-57642015DN92000014 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Angst, Débora Bartzen Moraes de Figueiredo, Nathália Stela Visoná Passarelli, Valmir Baldocchi, Meire Argentoni Rocha, Maria Sheila Guimarães Brucki, Sonia Maria Dozzi Autoimmune limbic encephalitis: A manifestation of systemic lupus erythematosus in the central nervous system |
title | Autoimmune limbic encephalitis: A manifestation of systemic lupus
erythematosus in the central nervous system |
title_full | Autoimmune limbic encephalitis: A manifestation of systemic lupus
erythematosus in the central nervous system |
title_fullStr | Autoimmune limbic encephalitis: A manifestation of systemic lupus
erythematosus in the central nervous system |
title_full_unstemmed | Autoimmune limbic encephalitis: A manifestation of systemic lupus
erythematosus in the central nervous system |
title_short | Autoimmune limbic encephalitis: A manifestation of systemic lupus
erythematosus in the central nervous system |
title_sort | autoimmune limbic encephalitis: a manifestation of systemic lupus
erythematosus in the central nervous system |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619358/ https://www.ncbi.nlm.nih.gov/pubmed/29213961 http://dx.doi.org/10.1590/1980-57642015DN92000014 |
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