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Rationale for launching a new journa

Vascular cognitive impairment/vascular dementia have been the subject of a large number of studies, due to their high prevalence and broad preventive and compensatory therapeutic potential. The knowledge of the cerebral anatomy correlated to the vascular territories of irrigation enables understandi...

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Detalles Bibliográficos
Autor principal: Nitrini, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619376/
https://www.ncbi.nlm.nih.gov/pubmed/29213360
http://dx.doi.org/10.1590/S1980-57642008DN10100001
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author Nitrini, Ricardo
author_facet Nitrini, Ricardo
author_sort Nitrini, Ricardo
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description Vascular cognitive impairment/vascular dementia have been the subject of a large number of studies, due to their high prevalence and broad preventive and compensatory therapeutic potential. The knowledge of the cerebral anatomy correlated to the vascular territories of irrigation enables understanding of clinical manifestations, as well as classification into the several types of syndromic presentations. The central cholinergic system exercises important neuromodulatory functions on cerebral circuits related to cognitive and behavioral integration, as well as on vasomotor control related to cerebral blood flow adjustments. The acquisition of data on the anatomy of the cholinergic pathways, including the localization of the nuclei of the basal prosencephalon and the routes of their projections, established an important milestone. The knowledge of the vascular distribution and of the trajectories of the cholinergic pathways allows identification of the strategic points where a vascular lesion can cause interruption. The ensuing denervation leads to cholinergic hypofunction in the involved territories. This information proves important to better evaluate the sites of vascular lesions, emphasizing their strategic localizations in relation to the cholinergic pathways, and offering more robust foundations for treatment aiming at enhancing cholinergic activity.
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spelling pubmed-56193762017-12-06 Rationale for launching a new journa Nitrini, Ricardo Dement Neuropsychol Editorial Vascular cognitive impairment/vascular dementia have been the subject of a large number of studies, due to their high prevalence and broad preventive and compensatory therapeutic potential. The knowledge of the cerebral anatomy correlated to the vascular territories of irrigation enables understanding of clinical manifestations, as well as classification into the several types of syndromic presentations. The central cholinergic system exercises important neuromodulatory functions on cerebral circuits related to cognitive and behavioral integration, as well as on vasomotor control related to cerebral blood flow adjustments. The acquisition of data on the anatomy of the cholinergic pathways, including the localization of the nuclei of the basal prosencephalon and the routes of their projections, established an important milestone. The knowledge of the vascular distribution and of the trajectories of the cholinergic pathways allows identification of the strategic points where a vascular lesion can cause interruption. The ensuing denervation leads to cholinergic hypofunction in the involved territories. This information proves important to better evaluate the sites of vascular lesions, emphasizing their strategic localizations in relation to the cholinergic pathways, and offering more robust foundations for treatment aiming at enhancing cholinergic activity. Associação de Neurologia Cognitiva e do Comportamento 2007 /pmc/articles/PMC5619376/ /pubmed/29213360 http://dx.doi.org/10.1590/S1980-57642008DN10100001 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Nitrini, Ricardo
Rationale for launching a new journa
title Rationale for launching a new journa
title_full Rationale for launching a new journa
title_fullStr Rationale for launching a new journa
title_full_unstemmed Rationale for launching a new journa
title_short Rationale for launching a new journa
title_sort rationale for launching a new journa
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619376/
https://www.ncbi.nlm.nih.gov/pubmed/29213360
http://dx.doi.org/10.1590/S1980-57642008DN10100001
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