Cargando…
Neuroprotective actions of 2,4-dinitrophenol: Friend or foe?
2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-β peptide. Since then, a...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Neurologia Cognitiva e do
Comportamento
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619426/ https://www.ncbi.nlm.nih.gov/pubmed/29213408 http://dx.doi.org/10.1590/S1980-57642008DN10400002 |
_version_ | 1783267401312239616 |
---|---|
author | Ferreira, Sérgio Teixeira Felice, Fernanda Guarino De |
author_facet | Ferreira, Sérgio Teixeira Felice, Fernanda Guarino De |
author_sort | Ferreira, Sérgio Teixeira |
collection | PubMed |
description | 2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-β peptide. Since then, a number of other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear due to mild mitochondrial uncoupling and prevention of oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. This study discusses the evidence supporting beneficial neuroprotective actions of DNP. DNP and other compounds with similar biological activities may be of interest in the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders. |
format | Online Article Text |
id | pubmed-5619426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Associação de Neurologia Cognitiva e do
Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-56194262017-12-06 Neuroprotective actions of 2,4-dinitrophenol: Friend or foe? Ferreira, Sérgio Teixeira Felice, Fernanda Guarino De Dement Neuropsychol Views & Reviews 2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-β peptide. Since then, a number of other studies have provided evidence of beneficial actions of DNP (at low concentrations), including neuroprotection against different types of insult, blockade of amyloid aggregation, stimulation of neurite outgrowth and neuronal differentiation, and even extension of lifespan in certain organisms. Some of these effects appear due to mild mitochondrial uncoupling and prevention of oxidative stress, whereas other actions are related to activation of additional intracellular signaling pathways. This study discusses the evidence supporting beneficial neuroprotective actions of DNP. DNP and other compounds with similar biological activities may be of interest in the development of novel therapeutic approaches for neurodegenerative diseases and other neurological disorders. Associação de Neurologia Cognitiva e do Comportamento 2007 /pmc/articles/PMC5619426/ /pubmed/29213408 http://dx.doi.org/10.1590/S1980-57642008DN10400002 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Views & Reviews Ferreira, Sérgio Teixeira Felice, Fernanda Guarino De Neuroprotective actions of 2,4-dinitrophenol: Friend or foe? |
title | Neuroprotective actions of 2,4-dinitrophenol: Friend or
foe? |
title_full | Neuroprotective actions of 2,4-dinitrophenol: Friend or
foe? |
title_fullStr | Neuroprotective actions of 2,4-dinitrophenol: Friend or
foe? |
title_full_unstemmed | Neuroprotective actions of 2,4-dinitrophenol: Friend or
foe? |
title_short | Neuroprotective actions of 2,4-dinitrophenol: Friend or
foe? |
title_sort | neuroprotective actions of 2,4-dinitrophenol: friend or
foe? |
topic | Views & Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619426/ https://www.ncbi.nlm.nih.gov/pubmed/29213408 http://dx.doi.org/10.1590/S1980-57642008DN10400002 |
work_keys_str_mv | AT ferreirasergioteixeira neuroprotectiveactionsof24dinitrophenolfriendorfoe AT felicefernandaguarinode neuroprotectiveactionsof24dinitrophenolfriendorfoe |