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A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis

Anti-NMDA receptor encephalitis is a severe but treatable autoimmune disease of the CNS. However, the use of immunotherapy and long-term outcomes have yet to be defined for this disease. We describe a case of an 18-year-old male diagnosed with anti-NMDAR encephalitis not associated with tumor, which...

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Autores principales: Simabukuro, Mateus Mistieri, Watanabe, Rafael Gustavo Sato, Pinto, Lécio Figueira, Guariglia, Carla, Gonçalves, Daniella Costa de Menezes e, Anghinah, Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação de Neurologia Cognitiva e do Comportamento 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619454/
https://www.ncbi.nlm.nih.gov/pubmed/29213885
http://dx.doi.org/10.1590/S1980-57642014DN81000014
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author Simabukuro, Mateus Mistieri
Watanabe, Rafael Gustavo Sato
Pinto, Lécio Figueira
Guariglia, Carla
Gonçalves, Daniella Costa de Menezes e
Anghinah, Renato
author_facet Simabukuro, Mateus Mistieri
Watanabe, Rafael Gustavo Sato
Pinto, Lécio Figueira
Guariglia, Carla
Gonçalves, Daniella Costa de Menezes e
Anghinah, Renato
author_sort Simabukuro, Mateus Mistieri
collection PubMed
description Anti-NMDA receptor encephalitis is a severe but treatable autoimmune disease of the CNS. However, the use of immunotherapy and long-term outcomes have yet to be defined for this disease. We describe a case of an 18-year-old male diagnosed with anti-NMDAR encephalitis not associated with tumor, which did not respond to initial treatment with immunoglobulin, followed by corticosteroids, cyclophosphamide and evolved with significant clinical improvement after a prolonged course of plasmapheresis. Although it is not possible to affirm the good outcome was due solely to the prolonged plasmapheresis regimen, recently published data shows that improvement may take weeks or months to occur. This case discloses another therapeutic possibility for patients with refractory disease who fail to respond to recommended first-line and second-line therapy.
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spelling pubmed-56194542017-12-06 A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis Simabukuro, Mateus Mistieri Watanabe, Rafael Gustavo Sato Pinto, Lécio Figueira Guariglia, Carla Gonçalves, Daniella Costa de Menezes e Anghinah, Renato Dement Neuropsychol Case Reports Anti-NMDA receptor encephalitis is a severe but treatable autoimmune disease of the CNS. However, the use of immunotherapy and long-term outcomes have yet to be defined for this disease. We describe a case of an 18-year-old male diagnosed with anti-NMDAR encephalitis not associated with tumor, which did not respond to initial treatment with immunoglobulin, followed by corticosteroids, cyclophosphamide and evolved with significant clinical improvement after a prolonged course of plasmapheresis. Although it is not possible to affirm the good outcome was due solely to the prolonged plasmapheresis regimen, recently published data shows that improvement may take weeks or months to occur. This case discloses another therapeutic possibility for patients with refractory disease who fail to respond to recommended first-line and second-line therapy. Associação de Neurologia Cognitiva e do Comportamento 2014 /pmc/articles/PMC5619454/ /pubmed/29213885 http://dx.doi.org/10.1590/S1980-57642014DN81000014 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Simabukuro, Mateus Mistieri
Watanabe, Rafael Gustavo Sato
Pinto, Lécio Figueira
Guariglia, Carla
Gonçalves, Daniella Costa de Menezes e
Anghinah, Renato
A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_full A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_fullStr A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_full_unstemmed A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_short A successful case of anti-NMDAR encephalitis without tumor treated with a prolonged regimen of plasmapheresis
title_sort successful case of anti-nmdar encephalitis without tumor treated with a prolonged regimen of plasmapheresis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619454/
https://www.ncbi.nlm.nih.gov/pubmed/29213885
http://dx.doi.org/10.1590/S1980-57642014DN81000014
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