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Computer-assisted 3D reconstruction of the human basal forebrain complex
The basal forebrain complex (BFC) is a small but intricate structure. Its organization and function is hard to investigate using conventional methods, especially in humans. By combining new methods of research we present a comprehensive overview of this complex, in order to better understand its fun...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação de Neurologia Cognitiva e do
Comportamento
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619561/ https://www.ncbi.nlm.nih.gov/pubmed/29213380 http://dx.doi.org/10.1590/s1980-57642008dn10200005 |
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author | Grinberg, Lea Tenenholz Heinsen, Helmut |
author_facet | Grinberg, Lea Tenenholz Heinsen, Helmut |
author_sort | Grinberg, Lea Tenenholz |
collection | PubMed |
description | The basal forebrain complex (BFC) is a small but intricate structure. Its organization and function is hard to investigate using conventional methods, especially in humans. By combining new methods of research we present a comprehensive overview of this complex, in order to better understand its function in normal and diseased brains. METHODS: The right and left BFC of a 29-year-old male were reconstructed from gallcocyanin (Nissl) stained 440 µm-thick serial horizontal sections by using advanced computer-assisted 3D reconstruction software. RESULTS: The reconstructed components in the present case include Ch2, Ch3, Ch4am-al, Ch4i, Ch4p, juxtacommissural, Ayala’s medial (subpallidal) and lateral (periputaminal) subnuclei. These components are arranged in an arch-like course mainly beneath the anterior commissure. The bilateral volume of all subnuclei was 99.06 mm(3), the left side accounting for 48.05 mm(3). Some of the subnuclei exhibited volume asymmetry indices varying from 28.3 to 12.9%.The volume of Ayalas’ lateral or periputaminal nucleus was 9.7% higher on the right, than on the left side. CONCLUSIONS: Our methodological approach promises to be highly efficient and reproducible in studying morphofunctional correlations in complex cognitive features |
format | Online Article Text |
id | pubmed-5619561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Associação de Neurologia Cognitiva e do
Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-56195612017-12-06 Computer-assisted 3D reconstruction of the human basal forebrain complex Grinberg, Lea Tenenholz Heinsen, Helmut Dement Neuropsychol Original Articles The basal forebrain complex (BFC) is a small but intricate structure. Its organization and function is hard to investigate using conventional methods, especially in humans. By combining new methods of research we present a comprehensive overview of this complex, in order to better understand its function in normal and diseased brains. METHODS: The right and left BFC of a 29-year-old male were reconstructed from gallcocyanin (Nissl) stained 440 µm-thick serial horizontal sections by using advanced computer-assisted 3D reconstruction software. RESULTS: The reconstructed components in the present case include Ch2, Ch3, Ch4am-al, Ch4i, Ch4p, juxtacommissural, Ayala’s medial (subpallidal) and lateral (periputaminal) subnuclei. These components are arranged in an arch-like course mainly beneath the anterior commissure. The bilateral volume of all subnuclei was 99.06 mm(3), the left side accounting for 48.05 mm(3). Some of the subnuclei exhibited volume asymmetry indices varying from 28.3 to 12.9%.The volume of Ayalas’ lateral or periputaminal nucleus was 9.7% higher on the right, than on the left side. CONCLUSIONS: Our methodological approach promises to be highly efficient and reproducible in studying morphofunctional correlations in complex cognitive features Associação de Neurologia Cognitiva e do Comportamento 2007 /pmc/articles/PMC5619561/ /pubmed/29213380 http://dx.doi.org/10.1590/s1980-57642008dn10200005 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Grinberg, Lea Tenenholz Heinsen, Helmut Computer-assisted 3D reconstruction of the human basal forebrain complex |
title | Computer-assisted 3D reconstruction of the human basal forebrain
complex |
title_full | Computer-assisted 3D reconstruction of the human basal forebrain
complex |
title_fullStr | Computer-assisted 3D reconstruction of the human basal forebrain
complex |
title_full_unstemmed | Computer-assisted 3D reconstruction of the human basal forebrain
complex |
title_short | Computer-assisted 3D reconstruction of the human basal forebrain
complex |
title_sort | computer-assisted 3d reconstruction of the human basal forebrain
complex |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619561/ https://www.ncbi.nlm.nih.gov/pubmed/29213380 http://dx.doi.org/10.1590/s1980-57642008dn10200005 |
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