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Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia
Selective disturbances of semantic memory have attracted the interest of many investigators and the question of the existence of single or multiple semantic systems remains a very controversial theme in the literature. OBJECTIVES: To discuss the question of multiple semantic systems based on a longi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação de Neurologia Cognitiva e do
Comportamento
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619570/ https://www.ncbi.nlm.nih.gov/pubmed/29213389 http://dx.doi.org/10.1590/s1980-57642008dn10200014 |
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author | Senaha, Mirna Lie Hosogi Caramelli, Paulo Porto, Claudia Sellitto Nitrini, Ricardo |
author_facet | Senaha, Mirna Lie Hosogi Caramelli, Paulo Porto, Claudia Sellitto Nitrini, Ricardo |
author_sort | Senaha, Mirna Lie Hosogi |
collection | PubMed |
description | Selective disturbances of semantic memory have attracted the interest of many investigators and the question of the existence of single or multiple semantic systems remains a very controversial theme in the literature. OBJECTIVES: To discuss the question of multiple semantic systems based on a longitudinal study of a patient who presented semantic dementia from fluent primary progressive aphasia. METHODS: A 66 year-old woman with selective impairment of semantic memory was examined on two occasions, undergoing neuropsychological and language evaluations, the results of which were compared to those of three paired control individuals. RESULTS: In the first evaluation, physical examination was normal and the score on the Mini-Mental State Examination was 26. Language evaluation revealed fluent speech, anomia, disturbance in word comprehension, preservation of the syntactic and phonological aspects of the language, besides surface dyslexia and dysgraphia. Autobiographical and episodic memories were relatively preserved. In semantic memory tests, the following dissociation was found: disturbance of verbal semantic memory with preservation of non-verbal semantic memory. Magnetic resonance of the brain revealed marked atrophy of the left anterior temporal lobe. After 14 months, the difficulties in verbal semantic memory had become more severe and the semantic disturbance, limited initially to the linguistic sphere, had worsened to involve non-verbal domains. CONCLUSIONS: Given the dissociation found in the first examination, we believe there is sufficient clinical evidence to refute the existence of a unitary semantic system. |
format | Online Article Text |
id | pubmed-5619570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Associação de Neurologia Cognitiva e do
Comportamento |
record_format | MEDLINE/PubMed |
spelling | pubmed-56195702017-12-06 Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia Senaha, Mirna Lie Hosogi Caramelli, Paulo Porto, Claudia Sellitto Nitrini, Ricardo Dement Neuropsychol Original Articles Selective disturbances of semantic memory have attracted the interest of many investigators and the question of the existence of single or multiple semantic systems remains a very controversial theme in the literature. OBJECTIVES: To discuss the question of multiple semantic systems based on a longitudinal study of a patient who presented semantic dementia from fluent primary progressive aphasia. METHODS: A 66 year-old woman with selective impairment of semantic memory was examined on two occasions, undergoing neuropsychological and language evaluations, the results of which were compared to those of three paired control individuals. RESULTS: In the first evaluation, physical examination was normal and the score on the Mini-Mental State Examination was 26. Language evaluation revealed fluent speech, anomia, disturbance in word comprehension, preservation of the syntactic and phonological aspects of the language, besides surface dyslexia and dysgraphia. Autobiographical and episodic memories were relatively preserved. In semantic memory tests, the following dissociation was found: disturbance of verbal semantic memory with preservation of non-verbal semantic memory. Magnetic resonance of the brain revealed marked atrophy of the left anterior temporal lobe. After 14 months, the difficulties in verbal semantic memory had become more severe and the semantic disturbance, limited initially to the linguistic sphere, had worsened to involve non-verbal domains. CONCLUSIONS: Given the dissociation found in the first examination, we believe there is sufficient clinical evidence to refute the existence of a unitary semantic system. Associação de Neurologia Cognitiva e do Comportamento 2007 /pmc/articles/PMC5619570/ /pubmed/29213389 http://dx.doi.org/10.1590/s1980-57642008dn10200014 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Senaha, Mirna Lie Hosogi Caramelli, Paulo Porto, Claudia Sellitto Nitrini, Ricardo Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia |
title | Verbal and non-verbal semantic impairment: From fluent primary
progressive aphasia to semantic dementia |
title_full | Verbal and non-verbal semantic impairment: From fluent primary
progressive aphasia to semantic dementia |
title_fullStr | Verbal and non-verbal semantic impairment: From fluent primary
progressive aphasia to semantic dementia |
title_full_unstemmed | Verbal and non-verbal semantic impairment: From fluent primary
progressive aphasia to semantic dementia |
title_short | Verbal and non-verbal semantic impairment: From fluent primary
progressive aphasia to semantic dementia |
title_sort | verbal and non-verbal semantic impairment: from fluent primary
progressive aphasia to semantic dementia |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619570/ https://www.ncbi.nlm.nih.gov/pubmed/29213389 http://dx.doi.org/10.1590/s1980-57642008dn10200014 |
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