Cargando…

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster

Genetic variants near and within the fatty acid desaturase (FADS) cluster are associated with polyunsaturated fatty acid (PUFA) biosynthesis, levels of several disease biomarkers and risk of human disease. However, determining the functional mechanisms by which these genetic variants impact PUFA lev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rahbar, Elaheh, Ainsworth, Hannah C., Howard, Timothy D., Hawkins, Gregory A., Ruczinski, Ingo, Mathias, Rasika, Seeds, Michael C., Sergeant, Susan, Hixson, James E., Herrington, David M., Langefeld, Carl D., Chilton, Floyd H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619705/ https://www.ncbi.nlm.nih.gov/pubmed/28957329 http://dx.doi.org/10.1371/journal.pone.0180903

Ejemplares similares

DNA Methylation in an Enhancer Region of the FADS Cluster Is Associated with FADS Activity in Human Liver
por: Howard, Timothy D., et al.
Publicado: (2014)

Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression
por: Reynolds, Lindsay M., et al.
Publicado: (2018)

Adaptive Evolution of the FADS Gene Cluster within Africa
por: Mathias, Rasika A., et al.
Publicado: (2012)

Impact of Genetic and Epigenetic Variations Within the FADS Cluster on the Composition and Metabolism of Polyunsaturated Fatty Acids in Prostate Cancer
por: Cui, Tao, et al.
Publicado: (2016)

Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes
por: Rahbar, Elaheh, et al.
Publicado: (2018)

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids
por: Reynolds, Lindsay M., et al.
Publicado: (2020)

Diet-Gene Interactions and PUFA Metabolism: A Potential Contributor to Health Disparities and Human Diseases
por: Chilton, Floyd H., et al.
Publicado: (2014)

The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
por: Mathias, Rasika A, et al.
Publicado: (2011)

Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases
por: Chilton, Floyd H., et al.
Publicado: (2017)

Impact of FADS gene variation and dietary fatty acid exposure on biochemical and anthropomorphic phenotypes in a Hispanic/Latino cohort
por: Sergeant, Susan, et al.
Publicado: (2023)

Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans
por: Sergeant, Susan, et al.
Publicado: (2016)

Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial
por: Dosso, Beverly, et al.
Publicado: (2020)

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
por: Yang, Chaojie, et al.
Publicado: (2021)

Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and FADS Genetic Variation
por: Chilton, Floyd H., et al.
Publicado: (2022)

Dietary Sources of Linoleic Acid (LA) Differ by Race/Ethnicity in Adults Participating in the National Health and Nutrition Examination Survey (NHANES) between 2017–2018
por: Momin, Shabnam R., et al.
Publicado: (2023)

Evolution of Hominin Polyunsaturated Fatty Acid Metabolism: From Africa to the New World
por: Harris, Daniel N, et al.
Publicado: (2019)

Intrinsic DNA topology as a prioritization metric in genomic fine-mapping studies
por: Ainsworth, Hannah C, et al.
Publicado: (2020)

Uncovering the Nutritional Landscape of Food
por: Kim, Seunghyeon, et al.
Publicado: (2015)

FALLING FOR FADS? Diagnostic and therapeutic fads in Psychiatry
por: Jesus, S., et al.
Publicado: (2022)

Blogs: fad or goldmine
por: Buckley, C
Publicado: (2003)

Correction: Uncovering the Nutritional Landscape of Food
Publicado: (2015)

Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations
por: Price, Alkes L., et al.
Publicado: (2009)

Winter Fads
Publicado: (1910)

The Latest Fad
Publicado: (1891)

The Gynæcological Fad
Publicado: (1895)

Fads in Medicine
por: Bogart, Henri
Publicado: (1915)

The genetics of smoking in individuals with chronic obstructive pulmonary disease
por: Obeidat, Ma’en, et al.
Publicado: (2018)

Uncovering Zn(2+) as a cofactor of FAD-dependent Pseudomonas aeruginosa PAO1 d-2-hydroxyglutarate dehydrogenase
por: Quaye, Joanna A., et al.
Publicado: (2023)

Liver DNA methylation of FADS2 associates with FADS2 genotypex
por: Walle, Paula, et al.
Publicado: (2019)

A higher plant FAD synthetase is fused to an inactivated FAD pyrophosphatase
por: Lynch, Joseph H., et al.
Publicado: (2022)

Secondary analyses for genome‐wide association studies using expression quantitative trait loci
por: Ngwa, Julius S., et al.
Publicado: (2022)

Uncovering the deubiquitinase activity landscape of breast cancer
por: Liu, Sijia, et al.
Publicado: (2020)

Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits
por: Winrow, Christopher J., et al.
Publicado: (2009)

Fads and fallacies : in name of science
por: Gardner, Martin, 1914-2010
Publicado: (1957)

Hypoglycemia, Fact or Fad
por: Greenbaum, Laurence
Publicado: (1984)

Fads and Fallacies in Psychiatry
por: Timms, Philip
Publicado: (2014)

Diet and Diet Fads
Publicado: (1908)

Another Food Fad
Publicado: (1916)

Is Radiotherapy a Fad?
Publicado: (1905)

Dietetic Fads and Proteinophoria
Publicado: (1913)

Cannot write session to /tmp/vufind_sessions/sess_208jnv7nn4ng78iou2lnajh2if