Cargando…

Pathway-based discovery of genetic interactions in breast cancer

Breast cancer is the second largest cause of cancer death among U.S. women and the leading cause of cancer death among women worldwide. Genome-wide association studies (GWAS) have identified several genetic variants associated with susceptibility to breast cancer, but these still explain less than h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wen, Xu, Zack Z., Costanzo, Michael, Boone, Charles, Lange, Carol A., Myers, Chad L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619706/ https://www.ncbi.nlm.nih.gov/pubmed/28957314 http://dx.doi.org/10.1371/journal.pgen.1006973

Ejemplares similares

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing
por: Becker, Jordan R., et al.
Publicado: (2015)

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens
por: Wagih, Omar, et al.
Publicado: (2013)

Discovering genetic interactions bridging pathways in genome-wide association studies
por: Fang, Gang, et al.
Publicado: (2019)

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network
por: Usaj, Matej, et al.
Publicado: (2017)

Genetic interactions reveal the evolutionary trajectories of duplicate genes
por: VanderSluis, Benjamin, et al.
Publicado: (2010)

DRYGIN: a database of quantitative genetic interaction networks in yeast
por: Koh, Judice L. Y., et al.
Publicado: (2010)

Conserved rules govern genetic interaction degree across species
por: Koch, Elizabeth N, et al.
Publicado: (2012)

Bringing order to protein disorder through comparative genomics and genetic interactions
por: Bellay, Jeremy, et al.
Publicado: (2011)

Protein Complexes are Central in the Yeast Genetic Landscape
por: Michaut, Magali, et al.
Publicado: (2011)

An integrated approach to characterize genetic interaction networks in yeast metabolism
por: Szappanos, Balázs, et al.
Publicado: (2011)

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions
por: Simpkins, Scott W., et al.
Publicado: (2018)

Global Linkage Map Connects Meiotic Centromere Function to Chromosome Size in Budding Yeast
por: Baryshnikova, Anastasia, et al.
Publicado: (2013)

A method for benchmarking genetic screens reveals a predominant mitochondrial bias
por: Rahman, Mahfuzur, et al.
Publicado: (2021)

Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical–Genetic Interactions
por: Safizadeh, Hamid, et al.
Publicado: (2021)

Visualization-based discovery and analysis of genomic aberrations in microarray data
por: Myers, Chad L, et al.
Publicado: (2005)

SUN-007 Discovery of Novel Signaling Pathways Downstream of PTK6 in TNBC Models
por: Dwyer, Amy, et al.
Publicado: (2019)

Comparison of Profile Similarity Measures for Genetic Interaction Networks
por: Deshpande, Raamesh, et al.
Publicado: (2013)

The Discovery of New Drug-Target Interactions for Breast Cancer Treatment
por: Song, Jiali, et al.
Publicado: (2021)

Histone modifications influence mediator interactions with chromatin
por: Zhu, Xuefeng, et al.
Publicado: (2011)

PheWAS-Based Systems Genetics Methods for Anti-Breast Cancer Drug Discovery
por: Gao, Min, et al.
Publicado: (2019)

Higher-order genetic interaction discovery with network-based biological priors
por: Pellizzoni, Paolo, et al.
Publicado: (2023)

Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression
por: Nguyen, Hai Dang, et al.
Publicado: (2013)

Pattern Discovery in Breast Cancer Specific Protein Interaction Network
por: Wu, Xiaogang, et al.
Publicado: (2009)

Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer
por: Young, Jonathan H., et al.
Publicado: (2016)

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
por: Aregger, Michael, et al.
Publicado: (2020)

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis
por: Mann, Paul A., et al.
Publicado: (2014)

Repression of essential cell cycle genes increases cellular fitness
por: Conti, Michelle M., et al.
Publicado: (2022)

Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
por: Salavert, Francisco, et al.
Publicado: (2016)

Gene set-based module discovery in the breast cancer transcriptome
por: Niida, Atsushi, et al.
Publicado: (2009)

Interaction-based discovery of functionally important genes in cancers
por: Ghersi, Dario, et al.
Publicado: (2014)

Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways
por: Enserink, Jorrit M.
Publicado: (2012)

An Integrative Multi-Network and Multi-Classifier Approach to Predict Genetic Interactions
por: Pandey, Gaurav, et al.
Publicado: (2010)

Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
por: Wang, Zailong, et al.
Publicado: (2007)

Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis
por: Nsamba, Emmanuel T., et al.
Publicado: (2021)

Explicit interaction information from WikiPathways in RDF facilitates drug discovery in the Open PHACTS Discovery Platform
por: Miller, Ryan A., et al.
Publicado: (2018)

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs
por: Mount, Harley O’Connor, et al.
Publicado: (2018)

Opportunities for Antigen Discovery in Metastatic Breast Cancer
por: Sood, Ashwani K., et al.
Publicado: (2020)

Improved discovery of genetic interactions using CRISPRiSeq across multiple environments
por: Jaffe, Mia, et al.
Publicado: (2019)

Mms1 and Mms22 stabilize the replisome during replication stress
por: Vaisica, Jessica A., et al.
Publicado: (2011)

Identification of Saccharomyces cerevisiae Spindle Pole Body Remodeling Factors
por: Greenland, Kristen B., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ck82ed4nm85l0jtb49vs3eg0fj