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Optimization to the Phellinus experimental environment based on classification forecasting method

Phellinus is a kind of fungus and known as one of the elemental components in drugs to avoid cancer. With the purpose of finding optimized culture conditions for Phellinus production in the lab, plenty of experiments focusing on single factor were operated and large scale of experimental data was ge...

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Detalles Bibliográficos
Autores principales: Li, Zhongwei, Xin, Yuezhen, Cui, Xuerong, Liu, Xin, Wang, Leiquan, Zhang, Weishan, Lu, Qinghua, Zhu, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619749/
https://www.ncbi.nlm.nih.gov/pubmed/28957375
http://dx.doi.org/10.1371/journal.pone.0185444
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author Li, Zhongwei
Xin, Yuezhen
Cui, Xuerong
Liu, Xin
Wang, Leiquan
Zhang, Weishan
Lu, Qinghua
Zhu, Hu
author_facet Li, Zhongwei
Xin, Yuezhen
Cui, Xuerong
Liu, Xin
Wang, Leiquan
Zhang, Weishan
Lu, Qinghua
Zhu, Hu
author_sort Li, Zhongwei
collection PubMed
description Phellinus is a kind of fungus and known as one of the elemental components in drugs to avoid cancer. With the purpose of finding optimized culture conditions for Phellinus production in the lab, plenty of experiments focusing on single factor were operated and large scale of experimental data was generated. In previous work, we used regression analysis and GA Gene-set based Genetic Algorithm (GA) to predict the production, but the data we used depended on experimental experience and only little part of the data was used. In this work we use the values of parameters involved in culture conditions, including inoculum size, PH value, initial liquid volume, temperature, seed age, fermentation time and rotation speed, to establish a high yield and a low yield classification model. Subsequently, a prediction model of BP neural network is established for high yield data set. GA is used to find the best culture conditions. The forecast accuracy rate more than 90% and the yield we got have a slight increase than the real yield.
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spelling pubmed-56197492017-10-17 Optimization to the Phellinus experimental environment based on classification forecasting method Li, Zhongwei Xin, Yuezhen Cui, Xuerong Liu, Xin Wang, Leiquan Zhang, Weishan Lu, Qinghua Zhu, Hu PLoS One Research Article Phellinus is a kind of fungus and known as one of the elemental components in drugs to avoid cancer. With the purpose of finding optimized culture conditions for Phellinus production in the lab, plenty of experiments focusing on single factor were operated and large scale of experimental data was generated. In previous work, we used regression analysis and GA Gene-set based Genetic Algorithm (GA) to predict the production, but the data we used depended on experimental experience and only little part of the data was used. In this work we use the values of parameters involved in culture conditions, including inoculum size, PH value, initial liquid volume, temperature, seed age, fermentation time and rotation speed, to establish a high yield and a low yield classification model. Subsequently, a prediction model of BP neural network is established for high yield data set. GA is used to find the best culture conditions. The forecast accuracy rate more than 90% and the yield we got have a slight increase than the real yield. Public Library of Science 2017-09-28 /pmc/articles/PMC5619749/ /pubmed/28957375 http://dx.doi.org/10.1371/journal.pone.0185444 Text en © 2017 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Zhongwei
Xin, Yuezhen
Cui, Xuerong
Liu, Xin
Wang, Leiquan
Zhang, Weishan
Lu, Qinghua
Zhu, Hu
Optimization to the Phellinus experimental environment based on classification forecasting method
title Optimization to the Phellinus experimental environment based on classification forecasting method
title_full Optimization to the Phellinus experimental environment based on classification forecasting method
title_fullStr Optimization to the Phellinus experimental environment based on classification forecasting method
title_full_unstemmed Optimization to the Phellinus experimental environment based on classification forecasting method
title_short Optimization to the Phellinus experimental environment based on classification forecasting method
title_sort optimization to the phellinus experimental environment based on classification forecasting method
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619749/
https://www.ncbi.nlm.nih.gov/pubmed/28957375
http://dx.doi.org/10.1371/journal.pone.0185444
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