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Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation

INTRODUCTION: Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C gene encoding GC-C cause Familial GUCY2C diarrhea syndrome (FGDS) which has been...

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Detalles Bibliográficos
Autores principales:	von Volkmann, Hilde L., Brønstad, Ingeborg, Gilja, Odd Helge, R. Tronstad, Rune, Sangnes, Dag Andre, Nortvedt, Ragnar, Hausken, Trygve, Dimcevski, Georg, Fiskerstrand, Torunn, Nylund, Kim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619782/ https://www.ncbi.nlm.nih.gov/pubmed/28957388 http://dx.doi.org/10.1371/journal.pone.0185496

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