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Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans

Nervous system function relies on precise synaptic connections. A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood. Taking advantage of known...

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Autores principales: Kim, Byunghyuk, Emmons, Scott W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619950/
https://www.ncbi.nlm.nih.gov/pubmed/28901288
http://dx.doi.org/10.7554/eLife.29257
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author Kim, Byunghyuk
Emmons, Scott W
author_facet Kim, Byunghyuk
Emmons, Scott W
author_sort Kim, Byunghyuk
collection PubMed
description Nervous system function relies on precise synaptic connections. A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood. Taking advantage of known connectivity in C. elegans, we identified and studied cell adhesion genes expressed in three interacting neurons in the mating circuits of the adult male. Two interacting pairs of cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsynaptic target interneuron AVG: BAM-2/neurexin-related in HOA binds to CASY-1/calsyntenin in AVG; SAX-7/L1CAM in sensory neuron PHC binds to RIG-6/contactin in AVG. A third, basal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of the other two. The features of this multiplexed mechanism help to explain how complex connectivity is encoded and robustly established during nervous system development.
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spelling pubmed-56199502017-09-29 Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans Kim, Byunghyuk Emmons, Scott W eLife Neuroscience Nervous system function relies on precise synaptic connections. A number of widely-conserved cell adhesion proteins are implicated in cell recognition between synaptic partners, but how these proteins act as a group to specify a complex neural network is poorly understood. Taking advantage of known connectivity in C. elegans, we identified and studied cell adhesion genes expressed in three interacting neurons in the mating circuits of the adult male. Two interacting pairs of cell surface proteins independently promote fasciculation between sensory neuron HOA and its postsynaptic target interneuron AVG: BAM-2/neurexin-related in HOA binds to CASY-1/calsyntenin in AVG; SAX-7/L1CAM in sensory neuron PHC binds to RIG-6/contactin in AVG. A third, basal pathway results in considerable HOA-AVG fasciculation and synapse formation in the absence of the other two. The features of this multiplexed mechanism help to explain how complex connectivity is encoded and robustly established during nervous system development. eLife Sciences Publications, Ltd 2017-09-13 /pmc/articles/PMC5619950/ /pubmed/28901288 http://dx.doi.org/10.7554/eLife.29257 Text en © 2017, Kim et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Kim, Byunghyuk
Emmons, Scott W
Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans
title Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans
title_full Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans
title_fullStr Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans
title_full_unstemmed Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans
title_short Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans
title_sort multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in c. elegans
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619950/
https://www.ncbi.nlm.nih.gov/pubmed/28901288
http://dx.doi.org/10.7554/eLife.29257
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