Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

During ageing, microglia acquire a phenotype that may negatively affect brain function. Here we show that ageing microglial phenotype is largely imposed by interferon type I (IFN-I) chronically present in aged brain milieu. Overexpression of IFN-β in the CNS of adult wild-type mice, but not of mice...

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Detalles Bibliográficos
Autores principales: Deczkowska, Aleksandra, Matcovitch-Natan, Orit, Tsitsou-Kampeli, Afroditi, Ben-Hamo, Sefi, Dvir-Szternfeld, Raz, Spinrad, Amit, Singer, Oded, David, Eyal, Winter, Deborah R., Smith, Lucas K., Kertser, Alexander, Baruch, Kuti, Rosenzweig, Neta, Terem, Anna, Prinz, Marco, Villeda, Saul, Citri, Ami, Amit, Ido, Schwartz, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620041/
https://www.ncbi.nlm.nih.gov/pubmed/28959042
http://dx.doi.org/10.1038/s41467-017-00769-0

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