General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity

General anesthetics are both neuroprotective and neurotoxic with unclear mechanisms. General anesthetics may control cell survival via their effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP(3)R-1). DT40 or SH-SY5Y cells with only or over 99% expression of InsP(3)R-1...

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Detalles Bibliográficos
Autores principales: Ren, Gongyi, Zhou, Yachun, Liang, Ge, Yang, Bin, Yang, Meirong, King, Alexander, Wei, Huafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620053/
https://www.ncbi.nlm.nih.gov/pubmed/28959036
http://dx.doi.org/10.1038/s41598-017-11607-0

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