Cargando…
MRAP2 regulates ghrelin receptor signaling and hunger sensing
Ghrelin is the only known circulating orexigenic hormone. It is primarily secreted by the stomach and acts at its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), in the hypothalamus to signal hunger and promote food intake. The melanocortin receptor accessory protein 2 (MRAP2) was pr...
Autores principales: | Srisai, Dollada, Yin, Terry C., Lee, Abigail A., Rouault, Alix A. J., Pearson, Nicole A., Grobe, Justin L., Sebag, Julien A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620068/ https://www.ncbi.nlm.nih.gov/pubmed/28959025 http://dx.doi.org/10.1038/s41467-017-00747-6 |
Ejemplares similares
-
The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells
por: Yin, Terry C., et al.
Publicado: (2020) -
MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation
por: Rouault, Alix A.J., et al.
Publicado: (2022) -
The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1
por: Chaly, Anna L, et al.
Publicado: (2016) -
Ghrelin at the interface of hunger, reward and obesity
por: Dickson, S. L.
Publicado: (2023) -
Hypothesis and Theory: Revisiting Views on the Co-evolution of the Melanocortin Receptors and the Accessory Proteins, MRAP1 and MRAP2
por: Dores, Robert M.
Publicado: (2016)