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Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming

Acute myeloid leukemia (AML) cells are highly dependent on glycolytic pathways to generate metabolic energy and support cell growth, hinting at specific, targetable vulnerabilities as potential novel targets for drug development. Elevated levels of NADPH, a central metabolic factor involved in redox...

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Detalles Bibliográficos
Autores principales:	Bhanot, Haymanti, Weisberg, Ellen L., Reddy, Mamatha M., Nonami, Atsushi, Neuberg, Donna, Stone, Richard M., Podar, Klaus, Salgia, Ravi, Griffin, James D., Sattler, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620199/ https://www.ncbi.nlm.nih.gov/pubmed/28978059 http://dx.doi.org/10.18632/oncotarget.18797

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