MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A

Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c d...

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Detalles Bibliográficos
Autores principales: Yuan, Daozhang, Zheng, Shunsheng, Wang, Liyan, Li, Jing, Yang, Jianan, Wang, Bin, Chen, Xiong, Zhang, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620201/
https://www.ncbi.nlm.nih.gov/pubmed/28978061
http://dx.doi.org/10.18632/oncotarget.18801
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author Yuan, Daozhang
Zheng, Shunsheng
Wang, Liyan
Li, Jing
Yang, Jianan
Wang, Bin
Chen, Xiong
Zhang, Xiaobo
author_facet Yuan, Daozhang
Zheng, Shunsheng
Wang, Liyan
Li, Jing
Yang, Jianan
Wang, Bin
Chen, Xiong
Zhang, Xiaobo
author_sort Yuan, Daozhang
collection PubMed
description Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.
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spelling pubmed-56202012017-10-03 MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A Yuan, Daozhang Zheng, Shunsheng Wang, Liyan Li, Jing Yang, Jianan Wang, Bin Chen, Xiong Zhang, Xiaobo Oncotarget Research Paper Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer. Impact Journals LLC 2017-06-28 /pmc/articles/PMC5620201/ /pubmed/28978061 http://dx.doi.org/10.18632/oncotarget.18801 Text en Copyright: © 2017 Yuan et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Yuan, Daozhang
Zheng, Shunsheng
Wang, Liyan
Li, Jing
Yang, Jianan
Wang, Bin
Chen, Xiong
Zhang, Xiaobo
MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
title MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
title_full MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
title_fullStr MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
title_full_unstemmed MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
title_short MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
title_sort mir-200c inhibits bladder cancer progression by targeting lactate dehydrogenase a
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620201/
https://www.ncbi.nlm.nih.gov/pubmed/28978061
http://dx.doi.org/10.18632/oncotarget.18801
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